Termination Of Anembryonic Pregnancy
الكلمات الدالة
نبذة مختصرة
تواريخ
آخر التحقق: | 09/30/2015 |
تم الإرسال لأول مرة: | 10/07/2015 |
تم إرسال التسجيل المقدر: | 10/07/2015 |
أول نشر: | 10/08/2015 |
تم إرسال آخر تحديث: | 10/07/2015 |
آخر تحديث تم نشره: | 10/08/2015 |
تاريخ بدء الدراسة الفعلي: | 05/31/2015 |
تاريخ الإنجاز الأساسي المقدر: | 09/30/2015 |
حالة أو مرض
التدخل / العلاج
Drug: Misoprostol
Drug: Misoprostol plus isosorbide mononitrate
Other: Misoprostol plus placebo
مرحلة
مجموعات الذراع
ذراع | التدخل / العلاج |
---|---|
Active Comparator: Misoprostol plus isosorbide mononitrate this group will receive 800 µg of misoprostol (Misotac 200 µg Sigma for Pharmaceutical Industries) plus 40 mg isosorbide mononitrate (Effox 40 mg Minipharma Company) will be inserted into the posterior vaginal fornix | Drug: Misoprostol plus isosorbide mononitrate 40 mg isosorbide mononitrate (Effox 40 mg Minipharma Company) |
Active Comparator: Misoprostol plus placebo This group will receive misoprostol 800 µg plus placebo in the same site. | Other: Misoprostol plus placebo |
معايير الأهلية
الأعمار المؤهلة للدراسة | 20 Years إلى 20 Years |
الأجناس المؤهلة للدراسة | Female |
يقبل المتطوعين الأصحاء | نعم |
المعايير | Inclusion Criteria: - Maternal age ≥20years old. - No vaginal bleeding. - No dilation of internal os. - Gestational age: from 8-11weeks. - Gestational sac with a mean gestational sac diameter (MGD) greater than 25 mm and no yolk sac, or an MGD >25 mm with no embryo. Exclusion Criteria: - Patients with excessive vaginal bleeding (soaking more than a pad per day). - Patients with dilated cervix. - Patients with allergy either to misoprostol or isosorbide mononitrate. - Those who will be insisted on D and C will be excluded from the study. - Women will be excluded from the study if they are anemic (hemoglobin less than 11 g/dl). - Hemo-dynamically unstable with signs of pelvic infection and/or sepsis. - Suffering from a clotting disorder or using anticoagulants. - Women with uterine pathology such as myomas or malformation. - Women had previous caesarian section. - Asthmatic patients. |
النتيجة
مقاييس النتائج الأولية
1. The measurement of endometrial thickness by ultrasound in mm [6 months]
مقاييس النتائج الثانوية
1. Induction - abortion interval in hours [6 months]
2. Induction dilatation interval in hours [6 month]
3. The occurrence of sever uncontrolled lower abdominal pain by visual analogue scale [6 months]