Behavior of secretion in the hypoxia-immobilisation stress on the rat.

Secretin was determined radioimmunologically in portal vein blood and in duodenal mucosa biopsies in stressed male Wistar rats as compared to control animals. The stressed animals showd a significantly higher scretin content of the duodenalmucosa and no different levels of the portal vein blood. A stress ulcer-reducing cimetidine application does not demonstrate any influence of secretin content on duodenal mucosa. The obvious elevation of duodenal secrtin is not the result of an increased gastric acid production, but may be a consequence of a stress-reduced susceptibility of the pancreas to endogenous secretin.