[Brenner tumor of the ovary--a clinicopathological report of 5 cases].

This paper reports 5 cases of Brenner tumor of the ovary treated in our hospital from 1967 to 1985. The patients' mean age was 54.6 years. Three lesions were solid, 1 cystic and the other occurred on the wall of a borderline malignant mucinous cystadenoma. All the 5 cases were benign by pathology. The clinical symptoms were abdominal pain in 3 cases, 2 of which had a torsion of the tumor pedicle, abdominal mass in 1 and abdominal swelling in the other. All the cases possessed the same feature that the tumor was composed of both hyperplastic epithelial nest and fibrous stroma. In histology, there were 3 transitional epithelial cell types and 2 basal cell-like types. Histogenesis of the Brenner tumor, according to the authors' observation, was shown by: 1. The epithelial cell nests of Brenner tumor were similar to the transitional epithelium of the urinary tract in 60% of these cases; basal-like cell in the early stage of differentiation comprised 40%, 2. In 80% of patients, there was observed, in the cell nuclei, a longitudinal groove, which resembled the cells of Walthard cell nests; 3. The transitional epithelial cells were found in the cyst wall of 1 polycystic tumor; another case was complicated with mucinous cystadenoma and there was no sharp demarcation between the two tumors under microscope. It suggests that the histogenesis imply that the Brenner tumor may arise from the coelomic epithelium of para-mesonephros. The authors also believe that certain Brenner tumors have endocrine activity, but the relation between which and the tumor stroma luteinization should be further studied.