Journal of Neurochemistry 1982-Jun
Calcium-dependent protease in neuroblastoma cells.
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Extracts of neuroblastoma cells contained calcium-dependent proteolytic activity. This activity was accounted for by two distinct proteases. These proteases were separated by ion-exchange chromatography. Although each was totally dependent on calcium, the calcium requirements of the enzymes were different; one enzyme required approximately 40 microM Ca2+ for half-maximal activity and the other enzyme required approximately 150 microM Ca2+ for half-maximal activity.