Acta Radiologica 2019-Apr
Comparison of conventional, diffusion, and perfusion MRI between infratentorial ganglioglioma and pilocytic astrocytoma.
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نبذة مختصرة
MATERIAL AND METHODS
This retrospective study enrolled 12 patients with infratentorial ganglioglioma and 61 patients with pilocytic astrocytoma who underwent MRI before surgery. DSC-PWI was performed in 20 patients (4 gangliogliomas, 16 pilocytic astrocytoma). Demographics, conventional imaging characteristics (tumor location, margin, cystic change, enhancement, peritumoral edema, and ipsilateral cerebellar atrophy), rADCmin, and rCBVmax ratio were compared. The optimum threshold, sensitivity, and specificity for rADCmin and rCBVmax ratios were determined.RESULTS
Infratentorial ganglioglioma appeared similar to pilocytic astrocytoma but was more likely to have an ill-defined margin ( P = 0.035), ipsilateral cerebellar atrophy ( P < 0.001), lower rADCmin ratio (1.24 ± 0.27 vs. 2.04 ± 0.46, P < 0.001), and higher rCBVmax ratio (3.05 ± 1.12 vs. 1.64 ± 0.39; P = 0.008). The threshold values ≤1.66 for rADCmin ratio provide sensitivity and specificity of 91.67% and 77.05%, respectively, for discriminating ganglioglioma from pilocytic astrocytoma. The optimal threshold value for rCBVmax ratio was >1.64.