[Disseminated intravascular coagulation and its pathogenetic significance in meningoencephalitis].

Combined investigation was performed in 370 patients with meningoencephalitis caused by different etiological factors. This comprised the clinical, laboratory, pathological (in 20 deceased patients) studies aimed at elucidating the role of cerebral microcirculation (CM) disorders in the pathogenesis of its inflammatory lesions. Disseminated intravascular coagulation (DIC) was detected in meningoencephalitides of various etiologies with all homeostatic links inflicted: blood vessels, platelets, coagulation. DIC had a major impact on the initiation, course and outcome of the disease. Severe microcirculatory disorders boosted the cerebral edema, promoted hemorrhagies. A close link was established between stage-by-stage nature of CM disorders development and clinical features of meningoencephalitis.