[Early cardiotoxicity of Hydroxychloroquine].
الكلمات الدالة
نبذة مختصرة
BACKGROUND
Hydroxychloroquine (HCQ) is most frequently used in the treatment of systemic inflammatory diseases. Cardiac complications of anti-malarial drugs are uncommon, and most of the time are the result of a long-term exposition. In this case, cardiotoxicity is the consequence of the lysosomal dysfunction and the result of intracytoplasmic granular material inclusions.
METHODS
We report a 77-year-old woman who presented a very early and reversible cardiotoxicity, probably related to the quinidine like effect of the HCQ, 10 days after initiation of therapy for Whipple endocarditis.
CONCLUSIONS
We discuss the different mechanisms of cardiotoxicity of anti-malarial drugs and their clinical manifestations.