South African Medical Journal 1985-Jun
High-dose ketoconazole therapy in prostatic cancer. A pilot study.
يمكن للمستخدمين المسجلين فقط ترجمة المقالات
الدخول التسجيل فى الموقع
يتم حفظ الارتباط في الحافظة
الكلمات الدالة
نبذة مختصرة
There may be contraindications to oestrogen therapy for prostatic carcinoma, and also patient objections to orchidectomy as a form of therapy. Ketoconazole, a systemic antifungal drug, was evaluated in a dosage of 200 mg 8-hourly given orally as an alternative method of lowering serum testosterone levels. Nineteen patients were studied; 1 was withdrawn because of nausea and vomiting. Only 6 patients (33,3%) had serum testosterone levels in the castrate range after 7 days. It seems that higher doses may be needed to keep testosterone levels consistently low.