Investigation of cardiovascular disease risk in women with uterine leiomyomas.

OBJECTIVE

The aim of this study was to investigate the cardiovascular disease risk of patients with uterine leiomyoma using carotid intima-media thickness (CIMT), insulin resistance and lipid profile.

METHODS

A total of 84 reproductive-aged women (20-45 years) were divided into two groups as the study group (n = 42) of women with leiomyoma and the control group (n = 42) of healthy women without leiomyoma. The risk factors for cardiovascular disease such as age, body mass index (BMI), low-density lipoprotein (LDL), triglycerides (Tg), high-density lipoprotein (HDL), total cholesterol and lipoprotein a levels, systemic disorders, cigarette smoking and CIMT were all recorded and compared between groups.

RESULTS

The mean age, gravida, parity, BMI, total cholesterol level and CIMT were significantly different between the groups (p < 0.05). CIMT after adjusted for the age and age, BMI was significantly lower in study groups (<0.001). Insulin resistance, serum LDL, Tg, HDL, lipoprotein a, and endometrial thickness were comparable between groups (p > 0.05). The number of leiomyoma was significantly correlated with Tg (r = 0. 322, p = 0.037) and LDL (r = 0. 431, p = 0.006). The size of leiomyoma was significantly correlated with HOMA-IR values (r = -0.370, p = 0.016).

CONCLUSIONS

Uterine leiomyoma was associated with lipid profile, insulin resistance and CIMT in reproductive-aged women.