[Lipid composition of blood serum and bile in biliary diseases in patients with diabetes mellitus].

OBJECTIVE

To study content and correlation of lipids in the serum and bile from diabetic patients with biliary diseases (BD).

METHODS

Serum and bile lipids were studied biochemically in 125 patients with BD and diabetes mellitus and 87 healthy control subjects aged 20-59 years. Serum lipids were studied biochemically as well as content and correlation of duodenal bile lipids. Correlation was investigated between blood and bile lipids.

RESULTS

Compared to healthy controls, diabetic patients with chronic cholecystitis and cholelithiasis had higher serum total cholesterol, triglycerides (by 28-34% and 63%, respectively) and a 18-22% decrease in HDLP cholesterol. Bile of such patients is oversaturated with cholesterol. Patients with diabetes type 2 had a close direct correlation between levels of total cholesterol, LDLP in the serum and Thomas-Hofmann index.

CONCLUSIONS

BD patients with diabetes mellitus had high levels of serum lipids and high bile concentrations of cholesterol. Serum and bile lipids concentrations direcly correlate.