Biochemical medicine and metabolic biology 1990-Dec
Modulation of the renin-aldosterone system by iodotyrosines as tyrosine hydroxylase inhibitors.
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نبذة مختصرة
This study shows that MIT and DIT stimulate aldosterone secretion. This may be due to their tyrosine hydroxylase inhibitory property. Dopamine abolishes the stimulation. Prolonged MIT administration enhances the stimulation of aldosterone secretion and can cause hypokalemia. Volume expansion reverses the hyperaldosteronism. PRA and blood pressure do not change, even after prolonged MIT intake.