Pollinosis: some immunologic and regional considerations and the description of Melia azedarach respiratory allergy.

Pollens constitute one of the most allergenic groups for man. Their prevalence make them an important factor when studying antigens that induce allergical diseases such as rhinitis, asthma, conjunctivitis, etc., wherein immunological mechanisms play a fundamental role. It is believed that genetic factors are involved in pollinosis and this could probably explain the enhanced susceptibility of certain individuals to acquire this type of allergy. Here we mention the HLA system, among others involved. Ecological aspects of each region must be carefully evaluated because of the importance of detecting the specific pollen area and the pollen's behaviour which, in turn, will permit an accurate etiological diagnosis. We have investigated a pollen widely spread in our province, called Melia azedarach and have demonstrated its property of inducing allergic respiratory disease. Finally, therapeutics in pollinosis is discussed and attention is paid to drugs such as antihistamines, ketotifen, among others but we think that specific immunotherapy plays a most important role.