Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 2004-May
[Potential influence of nicotine on inflammation and induction of autoantibodies in rats with adjuvant arthritis].
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الكلمات الدالة
نبذة مختصرة
The influence of chronic administration of nicotine diluted in the drinking water on the parameters of systemic inflammation and autoimmune processes in rats (August line) with adjuvant-induced arthritis, were studied. The experiments have shown that nicotine acts as an antiphlogistic means (the amount of C-reactive protein rises in the blood) and activates autoimmune processes: induction of rheumatic factor, of autoantibodies to serotonin, and glial fibrillar acid protein. It was supposed that nicotine has a potential impact on immunocompetent cells.