[Research of the relationship of ubiquinone and beclin-1 and liver mitochondria].

OBJECTIVE

To study whether CO-Q10 can protect liver injury caused by acute on chronic liver failure (ACLF) by autophagy.

METHODS

Rats were separated into three groups: control group, acute on chronic liver failure (ACLF) and intervenient group, liver tissues were observed by optical microscopy and electron microscopy. The levels of Beclin-1 expression were determined by real-time PCR. And Western Blot.

RESULTS

Areas of necrosis detected in intervenient group were alleviated than in ACLF significantly. Most mitochondrias had been degradated in ACLF group while alive in intervenient group. Real-time PCR and Western Blot revealed level of beclin-1 in ACLF was lower than control and intervenient group.

CONCLUSIONS

Intervenient group may ameliorate rat liver injury by promoting autophagy.