Syndrome of inappropriate secretion of antidiuretic hormone induced by intraarterial cisplatin chemotherapy.

BACKGROUND

Syndrome of inappropriate secretion of antidiuretic hormone induced by intraarterial cisplatin therapy is a previously unreported complication.

METHODS

A 63-year-old woman with stage Ib2 squamous cell carcinoma of the cervix was treated with intraarterial cisplatin infusion in a neoadjuvant setting. Four days following the second course of chemotherapy, she became drowsy with severe fatigue and decreased mental awareness. Blood tests showed sodium of 110 mEq/L. Urine and plasma osmolarities were 308 and 240 mOsm/kg, respectively, confirming the diagnosis of a syndrome of inappropriate secretion of antidiuretic hormone induced by intra-arterial cisplatin infusion.

CONCLUSIONS

The potential for development of clinically significant hyponatremia early in the course of cisplatin therapy with any infusion routes emphasizes the need to closely monitor patients.