Evaluation of the effects of concentrated growth factors or advanced platelet rich-fibrin on post-operative pain, edema, and trismus following lower third molar removal: A randomized controlled clinical trial.

The aim of this study was to investigate the effects of concentrated growth factors (CGF) and advanced platelet-rich fibrin (A-PRF) on edema, pain, and trismus after mandibular third molar surgery.

Patients were randomly divided into A-PRF, CGF and control groups. After extraction of the third molars, A-PRF and CGF were prepared and applied to the extraction sockets in study groups, while nothing was applied to the control group. Edema was measured from 5 reference points including tragus, labial commissure, soft tissue pogonion, lateral corner of the eye/lateral canthus and angulus mandible. Trismus measured as the distance between the right lower and upper right central incisors. Trismus and edema were measured preoperatively, and on postoperative 2^nd and 7^th days. Pain evaluated using the visual analogue scale (VAS) between 6^th hour and 7^th day after surgery.

A total of 75 patients, 25 in each group, were included in the study. The change in tragus to labial commissure measurements showed a significant difference between baseline-7^th days among control and CGF groups (P= 0.038). Significant differences observed between the tragus to pogonion measurements at baseline-7^th days among the control-CGF groups (P= 0.014), and A-PRF-CGF groups (P = 0.038). Secondary outcome variables trismus, pain, and analgesic consumption showed no significant differences among the groups (P > 0.05).

Based on the results of this study it can be concluded that A-PRF and CGF seem to have no positive effects on pain, edema, and trismus after third molar surgery.A-PRF, advanced platelet-rich fibrin; CGF, concentrated growth factors.