Extra-abdominal aggressive fibromatosis treated with meloxicam and sorafenib: An encouraging option

Objective: Aggressive fibromatosis (AF), also called desmoid tumor, is an uncommon soft-tissue neoplasm. Characteristically, it expands locally without metastatic potential. However, its tendency of relapse after curative resections has been well documented. Effective treatment options have been limited and there is a clear need for novel treatment strategies.

Methods: We used combination therapy including multikinase tyrosine kinase inhibitor for treating AF.

Results: We presented a case of an extra-abdominal AF who was successfully treated with meloxicam and sorafenib combination in our clinic. She tolerated this therapy well with only mild side effects. To our knowledge, this is the first case report of an extra-abdominal AF with a major partial response to sorafenib and meloxicam combination.

Conclusion: Due to the favorable toxicity profile of sorafenib and meloxicam, this combination might be an effective treatment option for patients with locally aggressive and inoperable AF.

Keywords: Aggressive fibromatosis; meloxicam; oral tyrosine kinase inhibitor; sorafenib.