agranulocytosis/وذمة

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Angioneurotic edema, agranulocytosis, and fatal septicemia following captopril therapy.

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Captopril, an angiotensin converting enzyme inhibitor used in the treatment of hypertension, has been associated with hematologic as well as dermatologic side effects. Two patients with captopril-induced angioneurotic edema, one of whom had fatal granulocytopenia and overwhelming polymicrobial

Pulmonary edema after glass bead microembolization: protective effect of granulocytopenia.

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Angioneurotic edema, agranulocytosis, and fatal septicemia following captopril therapy.

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Reduction of the edema of acute hyperoxic lung injury by granulocyte depletion.

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Increased numbers of granulocytes are found in lungs acutely injured by hyperoxia, but their contribution to lung injury remains unknown. We found that circulating granulocytes markedly increased (P less than 0.01) in rabbits exposed to hyperoxia for 72 h and that the numbers of granulocytes in lung

Clostridium difficile infection induced by pregabalin-associated agranulocytosis.

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A 33-year-old man who had recently undergone surgery for cervical spondylotic myelopathy was prescribed pregabalin for neuralgia, and the dose was increased to 600 mg/day during hospitalization. However, the patient was diagnosed with a Clostridium difficile infection on day 34 after admission. A

[DRESS syndrome and agranulocytosis, a rare combination].

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BACKGROUND Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe toxidermia that can lead to death from multivisceral failure. We report a case of DRESS associated with febrile agranulocytosis in a child. METHODS An 8-year-old child was hospitalized for diffuse maculopapular

Effect of granulocytopenia on extravascular lung water content after microembolization.

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We studied granulocyte entrapment in the lung after pulmonary microembolization to see if it contributes to the increase in extravascular water content. The lungs were embolized by intravenous injection of nonsiliconized glass beads (100 micrometers in diameter) in normal dogs and dogs made

Interleukin-1-induced granulocytopenia and pulmonary leukostasis in rabbits.

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Pulmonary leukostasis is a postulated prerequisite lesion for acute lung injury. Interleukin-1 (IL-1) mediates components of the acute-phase response, stimulates granulocyte metabolism and secretion, and augments endothelial adhesiveness. We studied the effects of murine IL-1 infusion on circulating

In vivo effects of intravascularly applied Escherichia coli hemolysin: dissociation between induction of granulocytopenia and lethality in monkeys.

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The effects of intravascular application of endotoxin-depleted Escherichia coli hemolysin (HlyA) was studied in rabbits and monkeys. In rabbits, bolus application of HlyA calculated to effect final blood levels of approximately 2-3 HU/ml (200-300 ng/ml) caused an acute fall of polymorphonuclear

Neutropenia in patients treated with thienopyridines and high-dose oral prednisone after percutaneous coronary interventions.

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BACKGROUND Oral treatment with prednisone has demonstrated efficacy in reducing restenosis after percutaneous coronary interventions (PCI). However, administration of steroids at high dose may raise concerns in terms of applicability and tolerability. Monitoring the occurrence of possible

Neuromyelitis optica spectrum disorder coinciding with hematological immune disease: A case report.

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BACKGROUND Recently defined consensus criteria for the diagnosis of neuromyelitis optica spectrum disorders (NMOSD) allow establishing the diagnosis in patients without elevated AQP4-Ab and optic nerve involvement. According to the new extended definition, NMOSD is closely associated with extensive

Production of acute pulmonary injury by leukocytes and activated complement.

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The adult respiratory distress syndrome (ARDS) frequently occurs after sepsis and major trauma. Since both sepsis and trauma may cause activation of the complement system, we have infused rabbits with complement-activated plasma (AP) and have studied the effects on leukocyte counts, respiratory

Continuous intravenous infusion of elastase in normal and agranulocytic minipigs--effects on the lungs and the blood coagulation system.

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In order to investigate the acute effects on lung morphology, lung function, hemodynamic and blood coagulation system, elastase (330 units (U) kg-1 h-1) was continuously infused into 16 anesthetized and mechanically ventilated minipigs. Elastase infusion induced a disturbance of blood coagulation

Endosulfan poisoning with intravascular hemolysis.

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We describe a 26-year-old female patient, who had attempted suicide with Endosulfan, and who presented to the Emergency Department with status epilepticus. She subsequently developed hypotension refractory to inotropes, intravascular hemolysis, disseminated intravascular coagulation (DIC), metabolic

A phase II trial of estramustine and etoposide in hormone refractory prostate cancer: A Southwest Oncology Group trial (SWOG 9407).

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BACKGROUND The combination of oral estramustine and oral etoposide has generated response rates of 40-50% in patients with hormone refractory prostate cancer in single institution trials. This study tested this regimen in a multi-institutional setting. METHODS Fifty-five patients were accrued over a

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