الصفحة 1 من عند 21 النتائج
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to the use of an opioid antagonist such as naltrexone in combination with one or more serotonin (5-hydroxytryptamine or 5-HT) or norepinephrine reuptake inhibitor(s) and/or lithium to treat mental or emotional
BACKGROUND OF THE INVENTION
Field of Invention
The present invention relates to androstane and pregnane steroid compounds and their use as allosteric modulators of the GABA receptor chloride ionophore complex and their use to alleviate stress, anxiety, mood disorders, seizures, depression, treatment
BACKGROUND OF THE INVENTION
Field of Invention
The present invention relates to androstane and pregnane steroid compounds and their use as allosteric modulators of the GABA receptor chloride ionophore complex and their use to alleviate stress, anxiety, mood disorders, seizures, depression, treatment
BACKGROUND OF THE INVENTION
1. Field of Invention
The present invention relates to androstane and pregnane steroid compounds and their use as allosteric modulators of the GABA receptor chloride ionophore complex and their use to alleviate stress, anxiety, mood disorders, seizures, depression,
TECHNICAL FIELD
The present invention is useful in medical fields. In more detail, novel imidazoline compounds of this invention are useful as neuropeptide Y receptor antagonists and as agents for the treatment of various kinds of cardiovascular disorders, central nervous system disorders, metabolic
This application is a 371 of PCT/JP01/01312 filed Feb. 22, 2001.
TECHNICAL FIELD
The present invention is useful in medical fields. In more detail, novel imidazoline compounds of this invention are useful as neuropeptide Y receptor antagonists and as agents for the treatment of various kinds of
TECHNICAL FIELD
The present disclosure relates to certain heterocycle fused morphianans. Compounds of the present disclosure are mixed mu agonist delta antagonists or dual mu agonist/delta agonists or antagonists at mu, delta and kappa opioid receptors. Compounds of the present disclosure are useful
CROSS-REFERENCE TO RELATED APPLICATION
This application claims, under 35 U.S.C. .sctn.119(a), the benefit of Korean Patent Application No. 10-2007-0084322 filed Aug. 22, 2007, the entire contents of which are incorporated herein by reference.
BACKGROUND OF THE INVENTION
1. Field of the Invention
The
This application is a U.S. national stage of International Application No. PCT/JP03/03115 filed Mar. 14, 2003.
TECHNICAL FIELD
The present invention is useful in medical fields. In more detail, novel pyridone derivatives of the present invention have an effect as neuropeptide Y receptor antagonists
FIELD OF THE INVENTION
The invention relates to glutaminyl cyclase (QC, EC 2.3.2.5) that catalyzes the intramolecular cyclization of N-terminal glutamine residues into pyroglutamic acid (5-oxo-prolyl, pGlu*) under liberation of ammonia and the intramolecular cyclization of N-terminal glutamate
FIELD OF THE INVENTION
The invention relates to glutaminyl cyclase (QC, EC 2.3.2.5) that catalyzes the intramolecular cyclization of N-terminal glutamine residues into pyroglutamic acid (5-oxo-prolyl, pGlu*) under liberation of ammonia and the intramolecular cyclization of N-terminal glutamate
The Sequence Listing, which is a part of the present disclosure, includes a computer readable form and a written sequence listing comprising nucleotide and/or amino acid sequences of the present invention. The sequence listing information recorded in computer readable form is identical to the
The Sequence Listing, which is a part of the present disclosure, includes a computer readable form and a written sequence listing comprising nucleotide and/or amino acid sequences of the present invention. The sequence listing information recorded in computer readable form is identical to the
INTRODUCTION
I. Field of the Invention
The present invention relates to: cells and non-human animals deficient for the protein kinase C isozyme .epsilon. (PKC.epsilon.); the use of PKC.epsilon. as a target for drugs; the use of modulators of PKC.epsilon. in methods of reducing anxiety, modulating
INTRODUCTION
FIELD OF THE INVENTION
The present invention relates to: cells and non-human animals deficient for the protein kinase C isozyme .epsilon. (PKC.epsilon.); the use of PKC.epsilon. as a target for drugs; the use of modulators of PKC.epsilon. in methods of reducing anxiety, modulating