alcoholism/triacylglycerol

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What factors control hepatic triacylglycerol accumulation in alcohol abuse?

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Acamprosate involvement in triacylglycerol hydrolysis and transacylation with cholesterol in chronically ethanol-drinking rats.

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Acamprosate (AC) is used as a drug for treating alcoholism. We evaluated the effect of AC on serum triacylglycerol hydrolysis (GEH, glycerol ester hydrolysis), triacylglycerol transacylation with cholesterol (GECAT, glycerol ester:cholesterol acyltransferase), and acylcholesterol hydrolysis (Cease,

Pattern of the adaptive response of erythrocyte glycerolipid acylation processes during chronic alcoholism.

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Challenging intact erythrocytes from normal human subjects with ethanol resulted in dose-dependent decreases in rates of acylation of phosphatidylcholine (PC) and phosphatidylethanolamine (PE) while triacylglycerol (TAG) acylation was stimulated. In erythrocytes from alcoholic subjects, the

Effects of N-acetylcysteine on alcohol abstinence and alcohol-induced adverse effects in rats.

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Alcoholism is rampant in modern society and some antioxidant compound could perhaps be useful to reduce the damage done by alcohol consumption and abstinence. The present study was undertaken to investigate the association of N-acetylcysteine (NAC) intake, alcoholism, and alcohol abstinence on lipid

Combination treatment of epilepsy with ketogenic diet and concurrent pharmacological inhibition of cytochrome P450 2E1.

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While most epileptic patients respond to treatment with existing antiepileptic drugs, there remains a considerable number of patients in whom these drugs do not suffice. Such patients, particularly children, are often treated using the ketogenic diet. This diet imposes a strict limit on

Weekend ethanol consumption and high-sucrose diet: resveratrol effects on energy expenditure, substrate oxidation, lipid profile, oxidative stress and hepatic energy metabolism.

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OBJECTIVE The present study analyzed the association between weekend ethanol and high-sucrose diet on oxygen consumption, lipid profile, oxidative stress and hepatic energy metabolism. Because resveratrol (RS, 3,5,4'-trans-trihydroxystilbene) has been implicated as a modulator of alcohol-independent

Magnesium deficiency in the rat increases tissue levels of docosahexaenoic acid.

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The effects of magnesium deficiency on tissue levels of total lipids and fatty acids were evaluated. Sprague-Dawley rats were fed a magnesium-deficient diet for 14 wk with controls being pair-fed to the deficient rats. Compared to the controls, serum and 24-h urinary magnesium levels were markedly

Lipid environment modulates the development of acute tolerance to ethanol in Caenorhabditis elegans.

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The development of tolerance to a drug at the level of the neuron reflects a homeostatic mechanism by which neurons respond to perturbations of their function by external stimuli. Acute functional tolerance (AFT) to ethanol is a fast compensatory response that develops within a single drug session

Deciphering non-alcoholic fatty liver disease through metabolomics.

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Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver disorders in industrialized countries. NAFLD develops in the absence of alcohol abuse and encompasses a wide spectrum of disorders ranging from benign fatty liver to non-alcoholic steatohepatitis (NASH). NASH often leads to

Serum magnesium levels in patients with alcoholic and non-alcoholic fatty liver.

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BACKGROUND Magnesium is currently a subject of major interest in biology and medicine. Magnesium is intimately involved in over 300 enzymatic reactions. particularly in processes involving the formation and utilization of ATP. It is known that alcoholism is connected with hypomagnesemia. There are

Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium.

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This report is a summary of a symposium on the role of S-adenosylmethionine (SAM), betaine, and folate in the treatment of alcoholic liver disease (ALD), which was organized by the National Institute on Alcohol Abuse and Alcoholism in collaboration with the Office of Dietary Supplements and the

Lipidomic signature of serum from the rats exposed to alcohol for one year.

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Alcohol abuse and its related diseases are the major risk factors for human health. Although the mechanism of alcohol-related disorders has been widely investigated, serum metabolites associated with long-term alcohol intake have not been well explored. In this study, we aimed to investigate the

Hypoxic right ventricular cardiomyopathy. A morphological and pathogenetic study on the myocardial atrophy and fatty infiltration.

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The autopsy report of an asymptomatic, non familial cardiomyopathy with widespread fatty infiltration of the right ventricular wall in two alcoholic subjects, who were also heavy smokers and suffering from a serious laryngeal obstruction, led the Authors to investigate, on the basis of a thorough

Cardiovascular disease prevention in eastern Europe.

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During the last 30 y the region of highest premature cardiovascular mortality has shifted from the US and Finland to Central and Eastern Europe. Present male cardiovascular mortality in Latvia, Estonia, the Russian Federation, and Hungary has overtaken the maximum cardiovascular mortality reached in

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