Decrease Post Laproscopy Shoulder and Abdominal Pain

as the selected surgery is diagnostic laparoscopy done only for female as this type of surgery there will be no source of pain other than abdominal distension

the investigator prepares syringes 1.75 ml/kg of 0.2% lidocaine (3.5 mg/kg) or the same volume of normal saline, for intraperitoneal administration. The solution to be instillated will be splashed under the right diaphragmatic area by the surgeon and complete the procedure.

Intraperitoneal lidocaine

pulmonary recruitment maneuver will be done and consist of five manual pulmonary inflations with a maximum pressure of 40 cm H2O. The anestheiologist hold the fifth positive pressure inflation for approximately 5 seconds

Pulmonary Recruitment

the investigator prepares syringes 1.75 ml/kg of 0.2% lidocaine (3.5 mg/kg) or the same volume of normal saline, for intraperitoneal administration. The solution to be instillated will be splashed under the right diaphragmatic area by the surgeon and complete the procedure before the recovery of the patient pulmonary recruitment maneuver will be done and consist of five manual pulmonary inflations with a maximum pressure of 40 cm H2O. The anestheiologist hold the fifth positive pressure inflation for approximately 5 seconds

Combined intraperitoneal lidocaine and pulmonary recruitment maneuver

Faculty of medicine CAIRO UNIVERISTY

Multimodal Analgesic Technique for Control of Post-laproscopy Abdominal Pain

Multimodal Analgesic Technique for Control of Post-laproscopy Abdominal Pain in Patient Undergoing Diagnostic Gynacological Laproscopy. A Randomized Controlled Trial

post-operative pain measured using Visual Analogue Scale ,The patients were asked to complete a 10-cm linear analogue scale for shoulder pain, which ranged from 0 for no pain at all to 10 for the worst pain imaginable

questionnaire will done for the patient at 8, 10 hour using VAS

Sherin Refaat

lecturer of Anesthiology at faculty of medicine Cairo univeristy

Cairo University

Subjects receive only one injection of NeoSTX in saline on the back of one calf (test side). Subjects receive NeoSTX in saline in subsequent dose escalation levels: 5mcg, 10mcg, 15mcg, 20mcg, 30mcg, and 40mcg NeoSTX.

Subjects receive only one injection of NeoSTX in combination with 0.2% bupivacaine on the back of one calf (test side). Subjects receive NeoSTX in bupivacaine in subsequent dose escalation levels: 5 mcg, 10 mcg, 15 mcg, 20 mcg, 30 mcg, and 40 mcg NeoSTX.

Subjects receive one injection of NeoSTX in bupivacaine 0.2% with epinephrine 5 mcg/ml on the back of one calf (test side). Subjects receive NeoSTX in bupivacaine 0.2% with epinephrine 5 mcg/ml in doses of 10 mcg or 30 mcg of NeoSTX.

Subjects receive one injection of saline on the back of one calf (test side).

Safety of Neosaxitoxin in Healthy Volunteers

NeoSTX will be administered in sequential dose cohorts. Each subject receives one injection with bupivacaine 0.2% alone on one side (control). On the other side they receive NeoSTX in saline (test). Subjects receive NeoSTX in saline in subsequent dose escalation levels: 5 mcg, 10 mcg, 15 mcg, 20 mcg, 30 mcg, and 40 mcg of NeoSTX.

Neosaxitoxin in saline

NeoSTX will be administered in sequential dose cohorts. Each subject receives one injection with bupivacaine 0.2% on one side (control). On the other side they receive NeoSTX with 0.2% bupivacaine. Subjects receive NeoSTX in 0.2% bupivacaine in subsequent dose escalation levels: 5 mcg, 10 mcg, 15 mcg, 20 mcg, 30 mcg, and 40 mcg of NeoSTX.

NeoSTX + bupivacaine 0.2%

Each subject receives one injection with bupivacaine 0.2% on one side (control). On the other side they receive NeoSTX in 0.2% bupivacaine with epinephrine 5 mcg/ml. Subjects receive NeoSTX in 0.2% bupivacaine with epinephrine 5 mcg/ml in doses of 10 mcg or 30 mcg of NeoSTX.

NeoSTX + bupivacaine 0.2% + epinephrine 5mcg/ml

Each subject receives one injection with bupivacaine 0.2% alone on one side. On the other side they receive saline placebo.

Saline placebo

Boston Children's Hospital

Safety Study of Long-Acting Local Anesthetic

Neosaxitoxin (NeoSTX) Alone and in Combination With Bupivacaine as Prolonged Duration Local Anesthetics: A Phase I Investigator-initiated Dose Escalation Study

measured by noninvasive quantitative sensory testing (QST)

Charles Berde

Chief, Division of Pain Medicine (Department of Anesthesiology, Perioperative, and Pain Medicine)

Migraine Headache

NPS 1776 (800 mg)

Placebo in non-carbonated fruit flavored drink (150 ml)

PLACEBO

NPS1776 in powdered form to be mixed with a non-carbonated fruit flavored drink

NPS 1776 (400 mg)

American Headache Society - Site dedicated to the study and treatment of headaches of all types including but not limited to migraines.

amide/نوبة

Multimodal Analgesic Technique for Control of Post-laproscopy Abdominal Pain

Safety Study of Long-Acting Local Anesthetic

Safety and Efficacy of NPS 1776 in the Acute Treatment of Migraine Headaches

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