anti aging/سرطان الثدي

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Caveolin-1 and accelerated host aging in the breast tumor microenvironment: chemoprevention with rapamycin, an mTOR inhibitor and anti-aging drug.

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Increasing chronological age is the most significant risk factor for human cancer development. To examine the effects of host aging on mammary tumor growth, we used caveolin (Cav)-1 knockout mice as a bona fide model of accelerated host aging. Mammary tumor cells were orthotopically implanted into

Bioidentical hormones, menopausal women, and the lure of the "natural" in U.S. anti-aging medicine.

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In 2002, the Women's Health Initiative, a large-scale study of the safety of hormone replacement therapy (HRT) for women conducted in the United States, released results suggesting that use of postmenopausal HRT increased women's risks of stroke and breast cancer. In the years that followed, as

Rapamycin increases breast tumor burden in young wheel-running mice.

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Rapamycin is an immunosuppressive and anti-cancer drug recently shown to enhance healthy aging in animal models. Regular physical exercise is associated with healthy aging and reduced risk of age-related diseases, such as cancer. In order to test the combined effect of these approaches, mice with

Upstream molecular signaling pathways of p27(Kip1) expression in human breast cancer cells in vitro: differential effects of 4-hydroxytamoxifen and deficiency of either D-(+)-glucose or L-leucine.

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BACKGROUND The objective of this study was to investigate whether the levels of glucose or certain amino acids could regulate the expression of a cell cycle repressor protein p27(Kip1), thereby dictating the risk of cancer in either obesity or caloric/dietary restriction. Previously, we identified

Walking a Tightrope: A Perspective of Resveratrol Effects on Breast Cancer.

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It is an acknowledged fact that health benefits are derived from fruit- and vegetables-enriched diets. In particular, polyphenols, compounds bearing one or more hydroxyl groups attached to an aromatic ring, are ascribed for most of such beneficial effects. Among them, resveratrol, a phytoalexin

Antiproliferative and pro-apoptotic activity of melatonin analogues on melanoma and breast cancer cells.

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Melatonin plays different physiological functions ranging from the regulation of circadian rhythms to tumor inhibition, owing to its antioxidant, immunomodulatory and anti-aging properties. Due to its pleiotropic functions, melatonin has been shown to elicit cytoprotective processes in normal cells

Cordycepin-induced apoptosis and autophagy in breast cancer cells are independent of the estrogen receptor.

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Cordycepin (3-deoxyadenosine), found in Cordyceps spp., has been known to have many therapeutic effects including immunomodulatory, anti-inflammatory, antimicrobial, and anti-aging effects. Moreover, anti-tumor and anti-metastatic effects of cordycepin have been reported, but the mechanism causing

A comparative study of anti-aging properties and mechanism: resveratrol and caloric restriction.

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Resveratrol and caloric restriction (CR) are the powerful therapeutic options for anti-aging. Here, their comparative effect on longevity-associated gene silencing information regulator (SIRT1) were evaluated in vitro and in vivo. IMR-90 cells treated with 2,2'-azobis (2-amidinopropane)

Klotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer.

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Klotho is an anti-aging gene, which has been shown to inhibit the insulin and insulin-like growth factor 1 (IGF-1) pathways in mice hepatocytes and myocytes. As IGF-1 and insulin regulate proliferation, survival and metastasis of breast cancer, we studied klotho expression and activities in human

Identification of prognostic biomarkers for breast cancer based on miRNA and mRNA co-expression network.

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Breast cancer (BC) remains a serious health threat for women due to its high incidence and the trend of rejuvenation. Accumulating evidence has highlighted that microRNAs (miRNAs) and messenger RNAs (mRNAs) could play important roles in various biological processes involved in the

Transforming growth factor beta orchestrates PD-L1 enrichment in tumor derived exosomes and mediates CD8 T cell dysfunction regulating early phosphorylation of TCR signalome in breast cancer

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Tumor cells promote immune evasion through up regulation of PD-L1 that binds with PD1 on cytotoxic T cells and promote dysfunction. Though therapeutic efficacy of anti PD1 antibody has remarkable effects on different type of cancers it is less effective in breast cancer. Hence more details

[Role of estrogen and selective estrogen receptor modulators in anti-aging].

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Changes in bone mass and estrogen levels occur in almost total sync with one another in a woman's lifecycle, with bone mass shown to increase in response to increases in estrogen in early adolescence and to decrease in response to decreases in estrogen during perimenopause. Therefore, menopause as

The Cytotoxicity Effect of Resveratrol: Cell Cycle Arrest and Induced Apoptosis of Breast Cancer 4T1 Cells.

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Resveratrol, a natural polyterpenoid, can scavenge reactive oxygen species in vivo to carry out the functions of antioxidation and antiaging. Resveratrol's anti-cancer capability has attracted widespread attention, but its molecular mechanism has not been systematically explained. In this study, by

Cellular senescence: from anti-cancer weapon to anti-aging target.

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Cellular senescence (CS) is a state of stable cell cycle arrest characterized by the production and secretion of inflammatory molecules. Early studies described oncogene-induced senescence (OIS) as a barrier to tumorigenesis, such that the therapeutic induction of CS might represent a rational

Fat grafting and stem cell enhanced fat grafting to the breast under oncological aspects--recommendations for patient selection.

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Reconstructive and aesthetic fat grafting has been introduced to the breast level over the last years. The safety of such procedures has so far not been completely clarified. The concept has now been refined to stem cell enhanced fat grafting. However beside the promise of using adult stem cells in

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Herbal & Natural Medicine

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