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Antidepressants and the risk of abnormal bleeding during spinal surgery: a case–control study.

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BACKGROUND Antidepressant medications are widely used by patients requiring spinal surgery. In spite of a generally favorable safety profile of newer antidepressants, several prior studies have suggested an association between use of serotonergic antidepressants and excessive bleeding. This study

Bleeding incidence with concomitant use of antidepressants and warfarin.

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BACKGROUND Bleeding is the major complication associated with warfarin therapy. Some antidepressants are also associated with increased bleeding risk. Warfarin and antidepressants are used frequently in combination, but it is unclear whether concomitant use increases the risk of bleeding beyond that

Use of serotonergic antidepressants and bleeding risk in patients undergoing surgery.

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BACKGROUND Serotonergic antidepressants (SADs) are associated with increased bleeding risk. OBJECTIVE To develop optimal guidelines for the usage of antidepressants in the perioperative period, this review of the bleeding risk associated with SADs was conducted. METHODS A total of 10 original

Antidepressant-induced adverse reactions in a patient with hemorrhagic stroke.

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OBJECTIVE To report a case of antidepressant-induced adverse drug reactions in a patient with hemorrhagic stroke. METHODS A 56-year-old man developed life-threatening adverse reactions after fluoxetine was added to his previously prescribed regimen of buspirone and olanzapine. One week after

The association between use of serotonergic antidepressants and perioperative bleeding during total hip arthroplasty--a cohort study.

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In vitro studies have shown that selective serotonin reuptake inhibitors inhibit platelet aggregation. It is well documented that SSRIs cause serious gastrointestinal bleeding, but studies on other bleeding manifestations have been equivocal. Our objective was to determine a possible association

Serotonin-Modulating Antidepressants and Risk of Bleeding after Trauma.

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Serotonin-modulating antidepressants have been associated with increased risk of gastrointestinal bleeding and increased blood loss during elective surgery. This study sought to investigate the effect of preinjury selective-serotonin reuptake inhibitor/serotonin-norepinephrine reuptake inhibitor

Antidepressant use and the risk of upper gastrointestinal bleeding in psychiatric patients: a nationwide cohort study in Taiwan.

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The magnitude of risk between selective serotonin reuptake inhibitors and upper gastrointestinal bleeding (UGIB) is still unknown in patients with psychiatric diseases. The aim of this study was to quantify the risk of UGIB induced by use of antidepressants with different affinities for serotonin

Antidepressants, warfarin, and the risk of hemorrhage.

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BACKGROUND Case reports suggest that some selective serotonin reuptake inhibitors can interact with warfarin to increase the likelihood of bleeding. We speculated that, among patients receiving warfarin, initiation of selective serotonin reuptake inhibitor treatment would be associated with an

Use of serotonergic antidepressants and bleeding risk in orthopedic patients.

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BACKGROUND Selective serotonin reuptake inhibitors have been associated with an increased bleeding tendency. Information on the impact of a possible impaired hemostasis associated with the perioperative use of selective serotonin reuptake inhibitors is limited. This study aimed to determine the

SSRI antidepressants: postpartum haemorrhage.

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One additional postpartum haemorrhage per 80 women exposed to an antidepressant that inhibits serotonin reuptake.

Association between warfarin combined with serotonin-modulating antidepressants and increased case fatality in primary intracerebral hemorrhage: a population-based study.

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OBJECTIVE Patients receiving oral anticoagulants run a higher risk of cerebral hemorrhage with a poor outcome. Serotonin-modulating antidepressants (selective serotonin reuptake inhibitors [SSRIs], serotonin-norepinephrine reuptake inhibitors [SNRIs]) are frequently used in combination with

Risk of upper gastrointestinal bleeding and the degree of serotonin reuptake inhibition by antidepressants: a case-control study.

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OBJECTIVE Selective serotonin reuptake inhibitor (SSRI) antidepressants can inhibit uptake of serotonin by platelets, and their use may predispose patients to bleeding. Case reports and observational studies from databases have suggested an association between the use of SSRIs and gastrointestinal

The risk of postpartum hemorrhage with selective serotonin reuptake inhibitors and other antidepressants.

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OBJECTIVE Limited evidence suggests that selective serotonin reuptake inhibitor (SSRI) antidepressants can hinder platelet aggregation and can increase the risk of hemorrhage. Because antenatal depression is common and is often treated with antidepressants, we sought to determine if exposure to SSRI

Antidepressants and the Risk of Hemorrhagic Stroke in the Elderly: a Nested Case-Control Study.

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Selective serotonin reuptake inhibitors (SSRIs) are frequently prescribed in the elderly due to a more favorable risk profile than other antidepressants (ADs). However, SSRIs are associated with an increased risk of gastrointestinal bleeding, while evidence on the risk of hemorrhagic

Serotonergic Antidepressants Are Associated with Increased Blood Loss and Risk for Transfusion in Single-Level Lumbar Fusion Surgery.

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METHODS Retrospective case-control study. OBJECTIVE The purpose of this study was to examine the effect of antidepressants on blood loss and transfusion requirements in spinal surgery patients. BACKGROUND Several studies have shown an increase in perioperative bleeding in orthopedic surgery patients

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