antidiabetic/سمنة

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Aromatic amino-alcohol derivatives having anti-diabetic and anti-obesity properties, their preparation and their therapeutic uses

يمكن للمستخدمين المسجلين فقط ترجمة المقالات

الدخول التسجيل فى الموقع

BACKGROUND OF THE INVENTION The present invention relates to a series of compounds which are characterised by a 2-[2-(substituted phenyl-oxy, thio or methyl)-1-methylethyl]aminoethanol structure and which have valuable anti-diabetic and anti-obesity activities; in addition, they are capable of

Aromatic amino-alcohol derivatives having anti-diabetic and anti-obesity properties, their preparation and their therapeutic uses

يمكن للمستخدمين المسجلين فقط ترجمة المقالات

الدخول التسجيل فى الموقع

BACKGROUND TO THE INVENTION The present invention relates to a series of compounds which are characterised by a 2-[2-(substituted phenyl-oxy, thio or methyl)-1-methylethyl]aminoethanol structure and which have valuable anti-diabetic and anti-obesity activities; in addition, they are capable of

Peptide with anti-obesity and anti-diabetic efficacy and use thereof

يمكن للمستخدمين المسجلين فقط ترجمة المقالات

الدخول التسجيل فى الموقع

TECHNICAL FIELD The present invention relates to a peptide having anti-obesity and/or anti-diabetic activities and including an amino acid sequence of SEQ ID NO: 1 or SEQ ID NO: 2, a pharmaceutical composition for prevention and/or treatment of obesity and/or diabetes, the pharmaceutical composition

Alkylated etiocholanolones and use as an anti-diabetic, anti-obesity and erythropoietic agent

يمكن للمستخدمين المسجلين فقط ترجمة المقالات

الدخول التسجيل فى الموقع

BACKGROUND OF THE INVENTION The major function of the adrenal gland is to regulate metabolism in the body so that an intermittent intake of food can be regulated to maintain a constant metabolite supply to the cells. This is accomplished by producing steroid hormones which can control the conversion

Substituted acid derivatives useful as anti-atherosclerotic, anti-dyslipidemic, anti-diabetic and anti-obesity agents and method

يمكن للمستخدمين المسجلين فقط ترجمة المقالات

الدخول التسجيل فى الموقع

FIELD OF THE INVENTION The present invention relates to novel substituted acid derivatives which modulate triglyceride levels, lipid levels, blood glucose levels, insulin levels, and non-esterified fatty acid (NEFA) levels, and thus are particularly useful in the treatment of atherosclerosis,

.alpha.-amino-indole-3-acetic acids useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents

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الدخول التسجيل فى الموقع

BACKGROUND OF THE INVENTION The present invention provides novel compounds. More particularly, the present invention provides novel .alpha.-amino-indole-3-acetic acids, tryptophans and their derivatives. The compounds are useful as anti-diabetic, anti-obesity and anti-atherosclerotic

Pharmaceutical composition for prevention and treatment of diabetes or obesity comprising a compound that inhibits activity of dipeptidyl peptidase-IV, and other antidiabetic or antiobesity agents as active ingredients

يمكن للمستخدمين المسجلين فقط ترجمة المقالات

الدخول التسجيل فى الموقع

CROSS-REFERENCE TO RELATED APPLICATIONS This application is a 371 of PCT/KR2009/005970 filed on Oct. 16, 2009, which claims the benefit of Korean Patent Application No. 10-2008-0101932 filed on Oct. 17, 2008, the contents of each of which are incorporated herein by reference. TECHNICAL FIELD The

Process for the preparation of arylethanolamine derivatives having an anti-obesity and anti-diabetic properties

يمكن للمستخدمين المسجلين فقط ترجمة المقالات

الدخول التسجيل فى الموقع

FIELD OF THE INVENTION This invention relates to a method for the preparation of certain biaryl derivatives. BACKGROUND OF THE INVENTION Atypical beta-adrenoceptors are known to occur in adipose tissue and the gastrointestinal tract. Atypical beta-adrenoceptor agonists have been found to be

Regulators of PPAR.delta. (.beta.) and their use in the treatment of obesity and insulin resistance

يمكن للمستخدمين المسجلين فقط ترجمة المقالات

الدخول التسجيل فى الموقع

FIELD OF THE INVENTION The present invention relates to a method for treating obesity, insulin resistance and dyslipidemia in mammals including humans through inhibition of PPAR.delta.(.beta.). This invention also relates to methods of screening for chemical entities that act to regulate

4-Alkyl-2,6-di-(secondary or tertiary alkyl)amino-3-formylpyridines pharmaceutical compositions thereof and their use in the treatment of obesity and diabetes

يمكن للمستخدمين المسجلين فقط ترجمة المقالات

الدخول التسجيل فى الموقع

This invention relates to compounds of the formula ##STR2## wherein R is secondary alkyl of 3 to 7 arbon atoms or tertiary alkyl of 4 to 7 carbon atoms, R' is secondary alkyl of 3 to 7 carbon atoms or tertiary alkyl of 4 to 7 carbon atoms, R.sub.1 is primary or secondary alkyl of 1 to 5 carbon

Benzisoxazole-derived antidiabetic compounds

يمكن للمستخدمين المسجلين فقط ترجمة المقالات

الدخول التسجيل فى الموقع

BACKGROUND OF THE INVENTION Diabetes refers to a disease process derived from multiple causative factors and characterized by elevated levels of plasma glucose or hyperglycemia. Uncontrolled hyperglycemia is associated with increased and premature mortality due to an increased risk for microvascular

Antidiabetic agents

يمكن للمستخدمين المسجلين فقط ترجمة المقالات

الدخول التسجيل فى الموقع

CROSS REFERENCE TO RELATED APPLICATIONS This application is a non-provisional application related to provisional application nos. 60/011,094 filed on Feb. 2, 1996 and 60/034,433 filed on Dec. 23, 1996, priority of which is claimed hereunder. BACKGROUND OF THE INVENTION Diabetes refers to a disease

Tocopherol and tocotrienol anti-obesity medicaments

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الدخول التسجيل فى الموقع

FIELD OF THE INVENTION The field of the invention is the use of tocopherols and tocotrienols in anti-obesity medicaments. BACKGROUND OF THE INVENTION Vitamin E consists of eight compounds; four tocopherols (alpha-, beta-, gamma-, and delta-) and four tocotrienols (alpha-, beta-, gamma-, and delta-).

Antidiabetic enolic glucoside of phenylpyruvic acid

يمكن للمستخدمين المسجلين فقط ترجمة المقالات

الدخول التسجيل فى الموقع

FIELD OF THE INVENTION The present invention relates to compounds for use as medicaments, especially normoglycemic agents, i.e. for lowering blood glucose levels to normal levels in mammals that are obese, pre-diabetic or have diabetes, obesity and/or syndrome X. BACKGROUND OF THE INVENTION Diabetes

Antidiabetic enolic glucoside of phenylpyruvic acid

يمكن للمستخدمين المسجلين فقط ترجمة المقالات

الدخول التسجيل فى الموقع

This application is a National Stage Application of PCT/EP2010/065052, filed 7 Oct. 2010, which application is incorporated herein by reference. To the extent appropriate, a claim of priority is made to the above disclosed application. FIELD OF THE INVENTION The present invention relates to

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