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[Post-marketing surveillance of acetylcysteine oral solution 17.6% "SENJU" for the antidote to acetaminophen overdose--use--results surveillance].

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Use-result surveillance was conducted to investigate the safety and efficacy of Acetylcysteine Oral Solution 17.6 % "SENJU" having the indication for the antidote to acetaminophen (Paracetamol) overdose. Ninety six cases (patients) were collected for the safety evaluation, and 13 cases (incidence

Clinical signs of ivermectin toxicity and the efficacy of antigabaergic convulsants as antidotes for ivermectin poisoning in epileptic chickens.

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The clinical signs of ivermectin toxicity were determined in 6 groups of 10 epileptic and 8 non-epileptic chickens for 72 h after dosing with sc injections of 5.0, 7.5, 10.0, 12.5 or 15.0 mg ivermectin/kg bw. At the 5.0 mg/kg dose, mild diarrhea developed 4 h post-dosing and lasted until the end of

Successful antidote of multiple lethal infections using sustained delivery of difluoromethylornithine by means of ceramic drug delivery devices.

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The objectives of this study were (1) to cure multiple infections of trypanosomiasis in rats by the sustained release of DFMO from biodegradable tricalcium phosphate (TCP) and aluminum-calcium-phosphorous oxide (ALCAP) delivery systems, and (2) to determine if the side effects associated with oral

Legalon® SIL: the antidote of choice in patients with acute hepatotoxicity from amatoxin poisoning.

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More than 90% of all fatal mushroom poisonings worldwide are due to amatoxin containing species that grow abundantly in Europe, South Asia, and the Indian subcontinent. Many cases have also been reported in North America. Initial symptoms of abdominal cramps, vomiting, and a severe cholera-like

[Paraquat poisoning mechanism and its clinical treatment progress].

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Paraquat (PQ) as a kind of sterile and herbicides, has effects of contact-kill and systemic action, which can be absorbed quickly by green plants and make them wither and die. Therefore, it is widely used in the agricultural production and occupies a large part in our country's pesticide market. PQ

Fatal i.v. colchicine injection in a 60-year-old woman.

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Colchicine is a rather benign drug when used appropriately and with an understanding of its potential side effects and toxicity. However, colchicine toxicity, though uncommon, is life-threatening. It is especially devastating to geriatric or debilitated patients because of its cumulative effects.

[Clinical manifestation and influential factors in patients with acute arsenic poisoning].

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OBJECTIVE To investigate the clinical characteristics of acute arsenic poisoning and its influential factors. METHODS Clinical data of 47 cases of arsenic poisoning were collected and analyzed. Two cases of observation, 40 cases of mild acute poisoning, and 5 severe acute poisoning were investigated

[Sodium azide: a review of biological effects and case reports].

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This report reviews the biological effects and case reports of suicidal or accidental ingestion of, and occupational exposure to sodium azide. Ingested doses of sodium azide were estimated for the 6 survival and 4 fatal cases studied. The lowest dose among survival cases was 5-10 mg. The patient

Reserpine toxicosis in a horse.

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A single injection of reserpine in an adult horse was believed to induce toxicosis for several days. Clinical signs included erratic, colic-like behavior followed by depression, bradycardia, miosis, ptosis, and paraphimosis. Diarrhea was not observed and may have been due to the effect of xylazine

Pulmonary thrombosis in acute organophosphate poisoning-Case report and literature overview of prothrombotic preconditioning in organophosphate toxicity.

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Acute organophosphate (OP) poisonings are presented with acetylcholine-receptor overstimulation. There have been a few case reports of thrombotic complications in acute OP poisonings, as well as prolonged thrombosis preconditions in patients who survived this type of intoxications. The

[Overdose with melphalan (Alkeran): symptoms and treatment. A review].

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The symptomatology and outcome of three of our own cases with Melphalan overdose are presented. The literature regarding Melphalan overdose and its toxicity when given in normal and high doses is reviewed. Two of our cases with injection of less than 100 mg/m2 recovered from marrow aplasia within 3

The veterinary importance of the toxic syndrome induced by ionophores.

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Monensin, lasalocid, salinomycin, narasin and maduramicin are carboxylic ionophores intended for use as anticoccidial drugs for poultry and as growth promotants for ruminants. Generally, ionophores have been found safe and effective in the target animals receiving recommended dosage levels. However,

Successful Resuscitation of a Young Girl Who Drank Rivastigmine With Respiratory Failure

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Rivastigmine is a non-competitive reversible inhibitor of acetylcholinesterase which is approved as one of the fi rst-line treatment options for Alzheimer's disease. We present the case of a 33-year-old woman with acute cholinergic syndrome secondary to deliberate rivastigmine poisoning. The patient

Acute abrin poisoning treated with continuous renal replacement therapy and hemoperfusion successfully: A case report.

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BACKGROUND Abrin is a highly toxic protein obtained from the seeds of Abrus precatorius, but poisoning due to ingestion of A precatorius is extremely rare in China. UNASSIGNED A 16-year-old girl, perfectly healthy before, was admitted to the department of gastroenterology owing to intentional

Protection by a transdermal patch containing physostigmine and procyclidine of soman poisoning in dogs.

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The prophylactic efficacy of a combinational patch system containing physostigmine and procyclidine against soman intoxication was evaluated using dogs. Female beagle dogs (body weights 9-10 kg) were shaved on the abdominal side, attached with a matrix-type patch (7x7 cm) containing 1.5% of

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