antithyroid/إعياء

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Regorafenib-induced hypothyroidism and cancer-related fatigue: is there a potential link?

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OBJECTIVE Thyroid dysfunction has been reported during Regorafenib (Reg) administration, but no detailed study is presently available. METHODS Prospective, observational cohort study. Patients with documented metastatic colorectal cancer and progression of disease during or within 3 months after the

[Anti-thyroid peroxidase in non-neoplastic thyroid pathology].

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Anti-thyroid peroxidase antibodies were prospectively assayed and compared with anti-microsome and anti-thyroglobulin antibodies in 203 patients (188 women, 15 men; mean age 42 +/- 14 years). These patients consulted for hyperthyroidism (n = 42, including 18 with Graves' disease), fumary

Endocrine-mediated mechanisms of fatigue during treatment with interferon-alpha.

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Fatigue occurs in more than 70% of patients treated with interferon-alpha (IFN-alpha) and is the most problematic toxicity associated with IFN-based immunotherapy. Abundant evidence suggests that immune-mediated endocrine disease occurs during IFN-alpha therapy, which may contribute to the etiology

Review of laboratory findings for patients with chronic fatigue syndrome.

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Various abnormalities revealed by laboratory studies have been reported in adults with chronic fatigue syndrome. Those most consistently reported include depressed natural killer cell function and reduced numbers of natural killer cells; low levels of circulating immune complexes; low levels of

Is antithyroid treatment really relevant for young patients with subclinical hyperthyroidism?

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This study investigated whether symptoms and findings of hyperthyroidism exist in patients with subclinical hyperthyroidism (SCH) and sought to determine whether hyperthyroidism treatment improves them. Twenty patients (mean age: 36.10 +/- 1.41 years) and 20 healthy controls [mean age: 36.35 +/-

The chronic fatigue syndrome: definition, current studies and lessons for fibromyalgia research.

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Chronic fatigue syndrome (CFS) is characterized by chronic, debilitating fatigue lasting greater than 6 months. Frequent chronic and recurrent findings include fever, pharyngitis, myalgias, adenopathy, arthralgias, difficulties in cognition and disorders of mood. In the majority of patients, the

The relationship of psychological factors to the prognosis of hyperthyroidism in antithyroid drug-treated patients with Graves' disease.

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OBJECTIVE The relationship between emotional stress and the onset of hyperthyroidism has been well investigated, but the relationship between psychological factors and prognosis of antithyroid drug-treated hyperthyroidism is not well known. This study has examined not only emotional stresses but

Improvement of Chronic Idiopathic Urticaria With Levothyroxine: A Case Report and Review of Literature.

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There is an increased association between chronic urticaria (CU) and thyroid autoantibodies. We presented a case of a patient suffering from CU and newly diagnosed Hashimoto's thyroiditis in which levothyroxine therapy completely resolved the symptoms of urticaria. A 58-year-old female with a past

Bartter's syndrome--case report.

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A 26-year-old female with Bartter's syndrome associated with Graves' disease is reported. This patient had a history of Graves' disease from the age of 22 and anti-thyroid drug (Methimazole) had been administered for 2 years. Thyroid function returned to normal but general fatigue and polyuria

[A case of iodide myxedema observed for 3 years under a low iodide diet--especially on the restoration of the mechanism of escape from the Wolff-Chaikoff effect].

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A 47-year-old housewife was admitted to our hospital because of general fatigue and constipation suggesting hypothyroidism. For 3 years before admission, general fatigue, arrhythmia, dry skin, drowsiness, cold intolerance and hypermenorrhea occurred insidiously. She had habitually taken considerable

Tubulointerstitial nephritis and uveitis syndrome associated with hyperthyroidism.

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We report a 17-year-old male patient with tubulointerstitial nephritis and uveitis (TINU) associated with hyperthyroidism. He presented with a 2-month history of fatigue, loss of appetite, low-grade fever, and a 12-kg weight loss when he was admitted to our hospital. He had iritis, which was

Thyrotoxicosis complicated with dysphagia.

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A 36-year-old man was admitted to our hospital because of general fatigue and dysphagia. He had experienced progression of thyrotoxic symptoms of weight loss, palpitation and sweating for several months. On admission, he showed thyroid storm associated with dysphagia and aspiration pneumonia.

Methimazole-induced cholestatic jaundice in an elderly hyperthyroid patient.

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BACKGROUND Hyperthyroidism is a common disease in the elderly. Antithyroid medications such as methimazole are one of the few treatment options. METHODS A 76-year-old white woman presented to the clinic with a 1-week history of fatigue, sleepiness, 7-pound weight loss, and tachycardia. Her blood

Propylthiouracil hepatitis: report of a case and extensive review of the literature.

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Antithyroid drugs (ATDs) have been widely and effectively used for the treatment of pediatric and adult thyrotoxicosis for more than a half century. Since the very beginning of ATD use, reports of hepatic dysfunction related to propylthiouracil (PTU) therapy have been published. We describe a case

Rapid progression from subclinical to symptomatic overt hypothyroidism.

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OBJECTIVE To report a case of Hashimoto's thyroiditis with rapid progression from subclinical to overt symptomatic hypothyroidism and to discuss the potential precipitating factors and the implications on clinical decisions about monitoring and treatment of early thyroid failure. METHODS We describe

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