Intervention: four non-aneurysmal patients undergoing coronary artery bypass graft or aortic valve replacement will be administered pimonidazole-HCl orally in a single dose (0.5g/m2) 24 hours prior to scheduled surgical time.

Intervention: four patients who are candidates for aortic replacement due to aneurysm will be administered pimonidazole-HCl orally in a single dose (0.5g/m2) 24 hours prior to scheduled surgical time.

Aortic Aneurysm, Thoracic

Pimonidazole hydrochloride

University of Pittsburgh Medical Center

Detection of Hypoxia in Human Thoracic Aorta Using Pimonidazole Hydrochloride

Levels of pimonidazole-HCl will be quantified in aortic specimens from patients who were administered pimonidazole-HCl prior to surgery

Thomas Gleason

Professor

This is a prospective study designed to determine the safety and value of pimonidazole hydrochloride to detect levels of tissue hypoxia in patients presenting with ascending aortic aneurysm

Complete cohort, which will be followed over 3 years

aortic rupture/نقص الأكسجة

Detection of Hypoxia in Human Thoracic Aorta Using Pimonidazole Hydrochloride

Is Obstructive Sleep Apnoea a Risk Factor for Thoracic Aortic Aneurysm Expansion? A Prospective Cohort Study.

قاعدة بيانات الأعشاب الطبية الأكثر اكتمالا التي يدعمها العلم