Patient will receive HIPEC in the form of Cisplatin 100mg/m2. 5. HIPEC will be provided at completion of surgical cytoreduction. The chemotherapy will be ordered by the treating gynecologic oncologist. It will be prepared in the chemotherapy pharmacy and delivered to the operating room once the surgeon confirms optimal cytoreduction and eligibility. Patients undergoing bowel resection will be left with bowel in discontinuity during the HIPEC infusion cycle. The abdomen will be temporarily closed with skin staples to prevent spillage of the perfusate. HIPEC will be delivered using the closed technique as has been well described.

Ovarian Cancer

Fallopian Tube Cancer

Primary Peritoneal Carcinoma

Heated Intraperitoneal Chemotherapy will be administered after the completion of interval cytoreductive surgery after three cycles of neoadjuvant chemotherapy.

Cisplatin

Long Island Jewish Medical Center

HIPEC After Initial CRS in Patients Who Have Received NACT

A Pilot Study of Heated Intraperitoneal Chemotherapy (HIPEC) After Interval Cytoreductive Surgery (CRS) in Patients Who Have Received Neoadjuvant Chemotherapy (NACT) for Epithelial Ovarian, Fallopian Tube and Primary Peritoneal Cancers

Severity of adverse events will be evaluated using the NCI Common Terminology Criteria for Adverse Events version 4.0 [NCI CTCAE v4.0]. AEs will be classified as possibly, probably, or definitely related to study treatment.

Physical examinations, vital signs, hematologic and clinical parameters, measured monthly for 12 months after initial study treatment or subject discontinuation, whichever comes first.

Time from surgery date to death due to any cause.

Time from surgery date to the first documentation of disease progression or death due to any cause.

Patient completion of systemic IV chemotherapy after surgery and HIPEC.

Survey administered to assess for quality of life.

Complete cytoreduction will be determined as having a CC score of 0 or 1

Target intra-peritoneal temperature of 41-43°C.

appendiceal neoplasms/غثيان

HIPEC After Initial CRS in Patients Who Have Received NACT

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