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atherosclerosis/حمى

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الصفحة 1 من عند 18 النتائج

Substituted heteroaryl analogs of 4,6-di-tertiary-butyl-5-hydroxy-1,3-pyrimidines useful as antiinflammatory agents

يمكن للمستخدمين المسجلين فقط ترجمة المقالات
الدخول التسجيل فى الموقع
BACKGROUND OF THE INVENTION The present invention is novel compounds which are 4,6-di-tertiary-butyl-5-hydroxy-1,3-pyrimidine substituted 1,2,4- and 1,3,4-thiadazoles and oxadiazoles, and 1,2,4-triazoles, and pharmaceutically acceptable acid addition or base salts thereof, pharmaceutical

3-aminocarbazole compound, pharmaceutical composition containing it and preparation method therefor

يمكن للمستخدمين المسجلين فقط ترجمة المقالات
الدخول التسجيل فى الموقع
FIELD OF THE INVENTION The present invention relates to novel 3-aminocarbazole compounds, to a pharmaceutical composition containing them, to a method for preparing them, and to the use of such compounds for the production of a drug that is useful in the treatment of disturbances associated with the

3-aminocarbazole compound, pharmaceutical composition containing it and preparation method therefor

يمكن للمستخدمين المسجلين فقط ترجمة المقالات
الدخول التسجيل فى الموقع
CROSS REFERENCES TO RELATED APPLICATIONS This application is a 371 of International Patent Application No. PCT/EP2009/055652, filed on May 11, 2009, and claims priority to European Patent Application No. 08425336.8, filed on May 14, 2008. FIELD OF THE INVENTION The present invention relates to novel

3-aminocarbazole compound, pharmaceutical composition containing it and preparation method therefor

يمكن للمستخدمين المسجلين فقط ترجمة المقالات
الدخول التسجيل فى الموقع
FIELD OF THE INVENTION The present invention relates to novel 3-aminocarbazole compounds, to a pharmaceutical composition containing them, to a method for preparing them, and to the use of such compounds for the production of a drug that is useful in the treatment of disturbances associated with the

Use of a benzoyl derivative of 3-aminocarbazole for the treatment of a disorder associated with the production of prostaglandin E.sub.2 (PGE.sub.2)

يمكن للمستخدمين المسجلين فقط ترجمة المقالات
الدخول التسجيل فى الموقع
FIELD OF THE INVENTION This invention relates to the use of a benzoyl derivative of 3-aminocarbazole in Table 1 below for the production of a pharmaceutical which is useful in the treatment of disorders associated with the production of prostaglandin E.sub.2 (PGE.sub.2) such as, for example,

Substituted 4,6-di-tertiary-butyl 5-hydroxy-pyrimidines

يمكن للمستخدمين المسجلين فقط ترجمة المقالات
الدخول التسجيل فى الموقع
BACKGROUND OF THE INVENTION The present invention is novel compounds which are 4,6-di-tertiary-butyl-5-hydroxy-1, 3-pyrimidine substituted 1,2,4- and 1,3,4-thiadazoles and oxadiazoles, and 1,2,4-triazoles, and pharmaceutically acceptable acid addition or base salts thereof, pharmaceutical

Isoxazolone compounds useful in treating diseases associated with unwanted cytokine activity

يمكن للمستخدمين المسجلين فقط ترجمة المقالات
الدخول التسجيل فى الموقع
TECHNICAL FIELD The present invention is directed to certain isoxazolone compounds that inhibit the release of inflammatory cytokines such as interleukin-1 (IL-1) and tumor necrosis factor (TNF) from cells. The compounds of the invention, therefore, are useful in treating diseases involving unwanted

Isoxazolone compounds useful in treating diseases associated with unwanted cytokine activity

يمكن للمستخدمين المسجلين فقط ترجمة المقالات
الدخول التسجيل فى الموقع
TECHNICAL FIELD The present invention is directed to certain isoxazolone compounds that inhibit the release of inflammatory cytokines such as interleukin-1 (1L-1) and tumor necrosis factor (TNF) from cells. The compounds of the invention, therefore, are useful in treating diseases involving unwanted

Substituted pyrido[2,3-d]pyrimidines as delta-5-desaturase inhibitors

يمكن للمستخدمين المسجلين فقط ترجمة المقالات
الدخول التسجيل فى الموقع
CROSS-REFERENCE TO RELATED APPLICATIONS This application is a U.S. national stage of International Application No. PCT/JP2011/066766 filed Jul. 22, 2011. TECHNICAL FIELD The present invention relates to a novel fused heterocyclic compound having superior properties as a medicament, and use thereof.

Pyrimidine compounds and their uses

يمكن للمستخدمين المسجلين فقط ترجمة المقالات
الدخول التسجيل فى الموقع
FIELD Described are novel heterocyclic compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and compositions, metabolites and prodrugs thereof. ##STR00002## The present invention also

Pyrimidine compounds and their uses

يمكن للمستخدمين المسجلين فقط ترجمة المقالات
الدخول التسجيل فى الموقع
FIELD Described are novel heterocyclic compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and compositions, metabolites and prodrugs thereof. ##STR00002## The present invention also

Heterocycles

يمكن للمستخدمين المسجلين فقط ترجمة المقالات
الدخول التسجيل فى الموقع
FIELD Described are novel heterocyclic compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and compositions, metabolites and prodrugs thereof. The present invention more particularly

Substituted heterocyclic compounds and methods of use

يمكن للمستخدمين المسجلين فقط ترجمة المقالات
الدخول التسجيل فى الموقع
BACKGROUND OF THE INVENTION The present invention comprises a new class of compounds useful in treating diseases, such as TNF-.alpha., IL-1.beta., IL-6 and/or IL-8 mediated diseases and other maladies, such as pain and diabetes. In particular, the compounds of the invention are useful for the

Substituted heterocyclic compounds and methods of use

يمكن للمستخدمين المسجلين فقط ترجمة المقالات
الدخول التسجيل فى الموقع
BACKGROUND OF THE INVENTION The present invention comprises a new class of compounds useful in treating diseases, such as TNF-.alpha., IL-1.beta., IL-6 and/or IL-8 mediated diseases and other maladies, such as pain and diabetes. In particular, the compounds of the invention are useful for the

Pyrimidine carboxamides

يمكن للمستخدمين المسجلين فقط ترجمة المقالات
الدخول التسجيل فى الموقع
FIELD OF THE INVENTION The present invention relates to novel compounds of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their solvates, their pharmaceutically acceptable salts and compositions, their
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