Treatment with KD will consist of 4:1 [fat]: [protein + carbohydrate] weight ratio. KD will be started as soon as the patient is ready for alimentation (while they are in neurocritical care unit). The rate of feeds will be calculated by trained dietician on service. Ketogenic diet will be continued during the entire length of ICU stay. Supplementation with vitamins, calcium and phosphorus will be done.

Traumatic Brain Injury

Ketogenic Dieting

Subjects will be provided with the Ketogenic diet in the form of tube feeds once the decision is made to start the patient on diet.

Ketogenic diet

University of Missouri Hospital

Ketogenic Diet for Traumatic Brain Injury

Safety and Feasibility of Ketogenic Diet for Traumatic Brain Injury Study Protocol

Intracranial Pressure will be measured hourly and it will be trended daily.

Serum beta-hydroxybutyrate will be done alternate day to assess the level of ketosis in blood.

CSF Ketone level will be measured to look for brain ketotic state.

Urine Ketones will be measured alternate day to assess the level of ketosis

Neurological exam will be documented with Glasgow Coma Scale.

Adverse effects like Diarrhea, vomiting, abdominal distension (ileus), abdominal tenderness will be monitored.

Lipid panel will be done weekly to check for alteration in lipid profile while subjects on KD.

Urinary Nitrogen and urinary creatinine will be measured alternate day to look for muscle wasting.

Niraj Arora

Assistant Professor

University of Missouri-Columbia

Treatment will consist of ketogenic diet. KD will consist of 4:1 [fat] : [protein+carbohydrate] weight ratio with 1600 kcal restriction. The diet will be supplemented with vitamins, calcium, phosphorus, zinc and selenium supplements to meet the requirements of US Dietary Reference Intakes (DRI) standard.

Glioblastoma Multiforme

ketogenic diet

MidAtlantic Epilepsy and Sleep Center

Ketogenic Diet as Adjunctive Treatment in Refractory/End-stage Glioblastoma Multiforme: a Pilot Study

Early treatment discontinuation, treatment compliance, 7-point Licker hunger scale, fasting lipid levels and fasting serum glucose and insulin levels

The secondary outcome measures will be (i) survival time and (ii) time to cerebral edema requiring steroid rescue treatment

brain edema/carbohydrate

Ketogenic Diet for Traumatic Brain Injury

Ketogenic Diet as Adjunctive Treatment in Refractory/End-stage Glioblastoma Multiforme: a Pilot Study

قاعدة بيانات الأعشاب الطبية الأكثر اكتمالا التي يدعمها العلم