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Influence of caffeine consumption on 7,12-dimethylbenz(a)anthracene-induced mammary gland tumorigenesis in female rats fed a chemically defined diet containing standard and high levels of unsaturated fat.

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The effect of caffeine (430-500 mg/liter of drinking water) on the initiation and promotion phases of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary gland tumorigenesis in female Sprague-Dawley rats fed a chemically defined diet containing standard (5%) or high (20%) levels of fat (corn oil)

Chromosome doubling of haploids of common wheat with caffeine.

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Treatment of dividing plant cells with caffeine inhibits their cytokinesis, thereby inducing the formation of binucleate cells that contain polyploid nuclei. This study was undertaken to determine whether caffeine treatments would induce chromosome doubling and seed set in haploids of common wheat

Effect of caffeine and alcohol on the toxicity and metabolism of methacrylonitrile in male Sprague-Dawley rats.

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This study reports the toxicity and metabolism of methacrylonitrile (MeAN) in normal male Sprague-Dawley rats and those pre-treated with caffeine, alcohol or both. Rats were divided into groups often. One group received an oral dose by gavage of 6 % MeAN solution in corn oil (equivalent to 0.5

Effect of metabolic inhibitors, methylxanthines, antioxidants, alkali metals, and corn oil on 1,2-dimethylhydrazine carcinogenicity in rats.

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The effect of the oral administration of 10 compounds on 1,2-dimethylhydrazine (DMH) carcinogenesis was investigated in 180 male Wistar rats and 510 male BD6 rats. DMH, administered s.c. once per week for 20 consecutive weeks (20 mg/kg body wt/dose), produced intestinal (mainly colon) tumors of

Inhibition and induction of drug metabolism by psoralens: alterations in duration of sleep induced by hexobarbital and in clearance of caffeine and hexobarbital in mice.

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1. Hexobarbital (100 mg/kg i.p.) sleeping times in male CD-1 mice pretreated (-1 h) with a single i.p. injection of 150 mumol/kg of psoralen or coumarin analogues were increased, most markedly (6-fold) by linear, methoxy-substituted psoralens. 2. Hexobarbital sleeping times of mice which received

Effects of Cola-Flavored Beverages and Caffeine on Streptococcus mutans Biofilm Formation and Metabolic Activity.

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OBJECTIVE To examine the effects of cola-flavored beverages and caffeine on growth and metabolism of Streptococcus mutans biofilm. This study was designed to determine if carbonated beverages or caffeine can increase S. mutans growth and biofilm formation and metabolic activity in vitro, potentially

Reduction of caffeine teratogenicity in mice by inducing maternal drug metabolism with beta-naphthoflavone.

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The effect of stimulating maternal drug metabolism on caffeine teratogenicity was investigated in C57BL/6J (cytochrome P1-450 inducible) and AKR/J (cytochrome P1-450 noninducible) mice. The inducing agent, beta-naphthoflavone (beta-NF) in corn oil, was administered intraperitoneally (IP) to dams at

The effect of caffeine, different fixation regimes and low temperature on microtubules in the cells of higher plants : Evidence for diversity in their response to chemical and physical treatments.

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Caffeine, (1:3:7-tri-methyl-xanthine), either as a prefixation treatment or included with glutaralde-hyde as the primary fixative, destroys or disorganises the microtubules associated with the formation of secondary walls in fibres from the flowering stem of the grass Lolium temulentum L. There is

High Fructose Corn Syrup Sweetened Soft Drink Consumption Increases Vascular Resistance in the Kidneys at Rest and during Sympathetic Activation.

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We first tested the hypothesis that consuming a high fructose corn syrup sweetened soft drink (HFCS) augments kidney vasoconstriction to sympathetic stimulation compared to water (Water, Study 1). In a second study, we examined the mechanisms underlying these observations (Study 2). In Study 1,

Regulative role of calcium signaling on methylglyoxal-improved heat tolerance in maize ( Zea mays L) seedlings

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Nowadays, calcium (Ca²⁺) and methylglyoxal (MG) are all deemed to be second messengers in plants, which participate in various physiological processes, such as seed germination, seedling establishment, plant growth and development, as well as response to environmental stress. However, the

Involvement of NO/cGMP pathway in toluene-induced locomotor hyperactivity in female rats.

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BACKGROUND Nitric oxide (NO) is implicated in the acute locomotor activating effects of some addictive drugs such as amphetamine, caffeine, and PCP, but has not been investigated in the case of toluene. OBJECTIVE This study determined the contribution of the NO-cyclic GMP (cGMP) pathway to locomotor

NTP Carcinogenesis Studies of Trichloroethylene (Without Epichlorohydrin) (CAS No. 79-01-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies).

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Trichloroethylene (TCE) is an industrial solvent used for vapor degreasing and cold cleaning of fabricated metal parts. TCE has also been used as a carrier solvent for the active ingredients of insecticides and fungicides, as a solvent for waxes, fats, resins, and oils, as an anesthetic for medical

Seminal prostaglandins in infertile men.

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The concentration of prostaglandin E (PGE) was measured in the semen of 5 men of proven fertility and in 12 men of couples who were infertile but in whom no abnormality had been detected by conventional semen analysis, postcoital test of sperm motility, endometrial biopsy, and laparoscopic dye

The effects of fasting on the acute oral toxicity of nine chemicals in the rat.

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Nine chemicals, with a range from extremely to slightly toxic, were used to measure the oral LD50 in both fasted (24-h) and non-fasted rats. Each chemical was tested as a solution or suspension in corn oil, responses within 14 days post-treatment were evaluated, and LD50S were calculated.

Toluene exposure increases aminophylline-induced seizure susceptibility in mice.

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The effects of toluene on the sensitivity to seizures induced by aminophylline were investigated. Mice were pretreated with an ip injection of corn oil or toluene (100-500 mg/kg) followed by a timed intravenous infusion of aminophylline at various time intervals to assess the seizure thresholds and

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