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مقالات التجارب السريرية براءات الاختراع

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The Risk of Mistaking Intestinal Lanthanum Carbonate for Intestinal Bleeding on CT.

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Lithium carbonate and granulocyte production: dose optimization.

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To determine the optimal dose of lithium for inducing granulocytosis, the authors administered lithium carbonate to normal volunteers at five dose levels. The authors performed assessments of circulating and marginated blood pools of granulocytes and of marrow reserve granulocytes to confirm that

Preoperative Preparation of Hyperthyroidism for Thyroidectomy - Role of Supersaturated Iodine and Lithium Carbonate.

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UNASSIGNED Thyroidectomy is effective and safe procedure for permanent cure of hyperthyroidism (HT). Iodine preparations are widely used before operation to prevent excess blood loss. Ideal regimen for refractory HT is debated. This retrospective case-control study is designed to study the efficacy

Capsule endoscopy for gastrointestinal bleeding with an obscure etiology.

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OBJECTIVE Capsule endoscopy (CE) is a new diagnostic modality that is being utilized with increasing frequency for examination of lesions suspected to be of small bowel origin. The most common indication for CE is obscure gastrointestinal bleeding. This study investigated the safety and diagnostic

The effect of lithium carbonate on lymphocyte, granulocyte, and platelet function.

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Lithium affects an increase in granulocyte counts in humans and has been promoted in the treatment of granulocytopenia and as adjuvant cancer chemotherapy to reduce the incidence of bacterial infections. In this study, eight healthy volunteers were studied by means of a panel of quantitative and

Pre-existing oral contrast from lanthanum carbonate: a confounding factor in CT mesenteric angiography.

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A 69-year-old male was referred from the renal unit to radiology for investigation of bleeding per rectum. A CT mesenteric angiogram was performed. However, it was noted on the pre-contrast images that the large bowel contained positive oral contrast media. The procedure was abandoned as it would

Impact of fluid therapy on apoptosis and organ injury during haemorrhagic shock in an oxygen-debt-controlled pig model.

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BACKGROUND Apoptosis, or programmed cell death, seems to play a role in the physiology of shock. The influence of fluid resuscitation on the occurrence of apoptosis during haemorrhage is still unclear. Using an experimental randomised study, the goal of this investigation was to find a relation

Modulation of microenvironmental pH for dual release and reduced in vivo gastrointestinal bleeding of aceclofenac using hydroxypropyl methylcellulose-based bilayered matrix tablet.

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This study was designed to develop a once-daily controlled-release matrix tablet of aceclofenac 200mg (AFC-CR) with dual release characteristics and to investigate the role of an alkalizer in enhancing drug solubility and reducing the occurrence of gastroduodenal mucosal lesions. Two formulation

A new method for measuring menstrual blood loss and its use in screening women before endometrial ablation.

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OBJECTIVE 1. To develop and validate a method for measuring menstrual blood loss in a routine setting, and 2. To assess the value of measuring menstrual blood loss before endometrial ablation. METHODS A prospective, observational study. METHODS Four Yorkshire hospitals: The General Infirmary at

A new and simple method of measuring menstrual blood loss.

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Although it is difficult for women to make reliable judgments about their menstrual blood loss, the direct measurement of such blood loss is useful in diagnosis and in evaluation of therapy. We developed a new and simple procedure for measuring blood on sanitary materials. The procedure is a

[Stomach tolerance of acetylsalicylic acid by addition of calcium carbonate. A study of a 2-treatment/3-period cross-over design].

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18 male volunteers (age 24 +/- 4 years; Broca index 0.94 +/- 0.08; mean +/- SD) underwent six upper endoscopies (three control and three test investigations) in a single blind two treatments-crossover designed study which evaluated the effect of buffering on aspirin-induced (one single oral dose of

Intraluminal hyperdense appearance of the small bowel on high resolution computed tomography of the abdomen and pelvis secondary to use of Calcium Carbonate tablets (Tums) mimicking a small bowel fistula

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Hyperdensity within the small bowel is most commonly seen with positive oral contrast agents, intraluminal hemorrhage and less likely an abnormal fistulous connection with the colon containing rectally administered contrast. We present the case of a 57-year-old female with a complex history of

A Nodular Foreign Body Reaction in a Dialysis Patient Receiving Long-term Treatment With Lanthanum Carbonate.

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A 63-year-old man with HIV (human immunodeficiency virus) infection and end-stage renal disease, treated with lanthanum carbonate phosphate binder for 4 years, presented with anemia and an upper gastrointestinal bleed. Upper endoscopy revealed a nodular hyperplastic epithelium, with an endoscopic

Gastrointestinal hemorrhage in aluminum phosphide poisoning.

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Poisoning, both accidental and intentional, is a significant contributor to the mortality and morbidity throughout the world. The commonest pesticide poisoning is organophosphates followed by phosphides. Ingestion of phosphides can induce severe gastrointestinal irritation leading to hemorrhage and

NADPH oxidase 1 is a novel pharmacological target for the development of an antiplatelet drug without bleeding side effects

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Growing evidence supports a central role of NADPH oxidases (NOXs) in the regulation of platelets, which are circulating cells involved in both hemostasis and thrombosis. Here, the use of Nox1^-/- and Nox1^+/+ mice as experimental models of human responses demonstrated a critical

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