PRIMARY OBJECTIVES:
I. To determine the clinical response of oral premalignant lesions to 12-14 weeks of metformin (metformin hydrochloride) intervention.
SECONDARY OBJECTIVES:
I. Histologic response to metformin intervention in the target lesion. II. Tissue-based biomarkers: metformin effect on
PRIMARY OBJECTIVES:
I. To determine the effect of escalating doses of metformin (metformin hydrochloride) given pre-operatively on pancreatic cancer cell proliferation and apoptosis.
SECONDARY OBJECTIVES:
I. To assess toxicity of escalating doses of metformin given pre-operatively in patients with
OBJECTIVES:
- Determine the metabolic status and regulation of primary T-cell acute lymphoblastic leukemia (T-ALL) relative to control resting peripheral T cells.
- Establish the effects of metabolic inhibition on metabolic stress pathways and apoptosis.
- Determine how metabolic inhibition
اكتب أحد الأعراض أو المرض واقرأ عن الأعشاب التي قد تساعد ، واكتب عشبًا واطلع على الأمراض والأعراض التي تستخدم ضدها. * تستند جميع المعلومات إلى البحوث العلمية المنشورة