The synthesis of fatty acids in all animals, plants, and bacteria includes a step in which acetyl-CoA is carboxylated to form malonyl-CoA. This reaction is catalyzed by acetyl-CoA carboxylase, which uses biotin as a cofactor in a two-step mechanism: ##STR1##
The first half-reaction is catalyzed by
FIELD OF THE INVENTION
The present invention concerns certain spirocyclic amides, compositions thereof, and methods of use thereof as pharmaceuticals, particularly in the treatment of obesity, metabolic syndrome, atherosclerosis, cardiovascular disease, insulin resistance, e.g., type II or
TECHNICAL FIELD
The present invention relates to a bicyclic compound having an acetyl-CoA carboxylase (in the present specification, sometimes to be abbreviated as ACC) inhibitory action, which is useful for the prophylaxis or treatment of cancer, inflammatory diseases and the like.
BACKGROUND OF
اكتب أحد الأعراض أو المرض واقرأ عن الأعشاب التي قد تساعد ، واكتب عشبًا واطلع على الأمراض والأعراض التي تستخدم ضدها. * تستند جميع المعلومات إلى البحوث العلمية المنشورة