chagas disease/triglyceride

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13 النتائج

Complement Factor H as a potential atherogenic marker in chronic Chagas' disease.

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We aimed to investigate the association between plasma levels of complement Factor H (FH) with cardiac involvement, inflammatory and cardiometabolic parameters in patients with chronic Chagas' disease (CD). FH plasmatic levels were determined in 80 chronic CD patients. Glycaemic index, lipidogram

The adipocyte as an important target cell for Trypanosoma cruzi infection.

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Adipose tissue plays an active role in normal metabolic homeostasis as well as in the development of human disease. Beyond its obvious role as a depot for triglycerides, adipose tissue controls energy expenditure through secretion of several factors. Little attention has been given to the role of

Trypanosoma cruzi infection is a potent risk factor for non-alcoholic steatohepatitis enhancing local and systemic inflammation associated with strong oxidative stress and metabolic disorders.

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BACKGROUND The immune mechanisms underlying experimental non-alcoholic steatohepatitis (NASH), and more interestingly, the effect of T. cruzi chronic infection on the pathogenesis of this metabolic disorder are not completely understood. RESULTS We evaluated immunological parameters in male C57BL/6

The association of infection and clinical severity in sickle cell anaemia patients.

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Sickle cell anaemia (SCA) patients have a high risk of infection. We retrospectively investigated the prevalence of infection among SCA patients from Bahia, Brazil. A total of 1415 SCA patients were studied between 1995 and 2009: 190 (13.4%) had hepatitis C virus (HCV), 67 (4.7%) had human

In vitro and in vivo activities of E5700 and ER-119884, two novel orally active squalene synthase inhibitors, against Trypanosoma cruzi.

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Chagas' disease is a serious public health problem in Latin America, and no treatment is available for the prevalent chronic stage. Its causative agent, Trypanosoma cruzi, requires specific endogenous sterols for survival, and we have recently demonstrated that squalene synthase (SQS) is a promising

Omega-3 supplementation on inflammatory markers in patients with chronic Chagas cardiomyopathy: a randomized clinical study.

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BACKGROUND Several studies have been focusing on the effect of omega-3 polyunsaturated fatty acids on modulation of inflammatory markers in several cardiopathies. Although immunoregulatory dysfunction has been associated to the chronic cardiac involvement in Chagas disease, there is no study

Phase Transitions of Isotropic to Anisotropic Biocompatible Lipid-Based Drug Delivery Systems Overcoming Insoluble Benznidazole Loading.

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Previous studies reported low benznidazole (BNZ) loading in conventional emulsions due to the weak interaction of the drug with the most common oils used to produce foods or pharmaceuticals. In this study, we focused on how the type of surfactant, surfactant-to-oil ratio w/w (SOR) and oil-to-water

Studies of membrane fluidity and heart contractile force in Trypanosoma cruzi infected mice.

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In Chagas disease serious cardiac dysfunction can appear. We specifically studied the cardiac function by evaluating: ventricle contractile force and norepinephrine response, affinity and density of beta-adrenergic receptors, dynamic properties of myocardial membranes, and electrocardiography.

[Increase of lipids in human chagasic placentas: cytochemical and biochemical study].

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It has been demonstrated that the normal human trophoblast has lipidic granules that contain triglycerides and phospholipids of yet unclear signification. With the purpose of analyzing the effect of Chagas disease on these structures, the present study was undertaken with the purpose of determining

Lipoprotein lipase in the fat body of Triatoma brasiliensis.

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Lipoprotein lipase activity was detected and characterized in the fat body of Triatoma brasiliensis one of the vector of Chagas' disease. The enzyme activity was close to a free fatty acid production of 47 mumol FFA mg protein-1-h-1 when assayed in the complete system. 2. The enzyme presented

Female alcoholics: electrocardiographic changes and associated metabolic and electrolytic disorders.

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OBJECTIVE To identify the electrocardiographic changes and their associations with metabolic and electrolytic changes in female alcoholics. METHODS The study comprised 44 female alcoholics with no apparent physical disorder. They underwent the following examinations: conventional

[Factors associated with orthostatic hypotension in adults: the ELSA-Brasil study].

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This study aimed to investigate factors associated with orthostatic hypotension in 14,833 individuals 35-74 years of age. This was a cross-sectional study of baseline data (2008-2010) from the Longitudinal Study of Adult Health (ELSA-Brasil). Postural testing was performed after 20 minutes resting

Tailoring microstructural, drug release properties, and antichagasic efficacy of biocompatible oil-in-water benznidazol-loaded nanoemulsions.

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This study explored the transition of lamellar-type liquid crystal (LLC) to biocompatible oil-in-water nanoemulsions able to modify benznidazole (BNZ) release and target the drug to cells infected with the T. cruzi parasite. Three cosolvents (2methylpyrrolidone [NMP], polyethylene glycol [POL], and

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