Valproic Acid taken orally, daily to reach serum levels between 50 to 100 µg/mL.

High Grade Sarcoma

Subjects should initiate therapy at 10 to 15 mg/kg/day. The dosage should be increased by 5 to 10 mg/kg/week to achieve optimal clinical response. Optimal clinical response is achieved at daily doses below 60 mg/kg/day. If satisfactory clinical response has not been achieved, plasma levels should be measured to determine whether or not they are in the usually accepted therapeutic range (50 - 100 µg/mL).

Valproic Acid

Columbia University Medical Center

Adjuvant Valproate for High Grade Sarcomas

A Pilot Study of Adjuvant Valproate for Patients With High Grade Sarcomas

The primary end point will be evaluated by the 3-year recurrence rate of lower grade sarcoma histopathologically (or more well differentiated as compared to the primary tumor) amongst those who experience 3-year sarcoma recurrence.

colorectal neoplasms/نوبة

Adjuvant Valproate for High Grade Sarcomas

قاعدة بيانات الأعشاب الطبية الأكثر اكتمالا التي يدعمها العلم