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Extracts of Scutellaria baicalensis reduced body weight and blood triglyceride in db/db Mice.

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Scutellaria baicalensis has been extensively employed for the clinical treatment of hyperlipidemia, atherosclerosis, hypertension, dysentery, inflammatory diseases, and the common cold. The present study was performed to investigate the anti-obesity and anti-dyslipidemia effect of Scutellaria

Therapeutic potential of mipomersen in the management of familial hypercholesterolaemia.

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High levels of low-density lipoprotein cholesterol (LDL-C) and lipoprotein(a) [Lp(a)] are associated with early morbidity and mortality caused by cardiovascular disease (CVD). There are hints that a reduction of LDL-C levels beyond currently advocated targets, and the use of drugs that also have

Preliminary studies on haematological and plasmatic parameters in gilthead sea bream (Sparus aurata) held under day/night temperature variations.

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This study aimed to evaluate to what extent diel water temperature oscillations over a short period of time (41 h) affected haematologic and plasmatic parameters of gilthead sea bream. Sea bream juveniles (160 fish; 177.2 ± 20.9 g) were divided in two homogenous groups, experimental and control. The

Garlic in clinical practice: an evidence-based overview.

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OBJECTIVE Garlic has been widely used in clinical practice, and there were many systematic reviews (SRs) describing its effects. But none reviewed the clinical utility comprehensively, so we aimed to evaluate its effects from every aspect of its effects. METHODS We comprehensively searched medical

Performance evaluation of thrombomodulin, thrombin-antithrombin complex, plasmin-α2-antiplasmin complex, and t-PA: PAI-1 complex.

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To conduct a comprehensive performance evaluation of a fully automated analyzer for measuring thrombomodulin (TM), thrombin-antithrombin complex (TAT), plasmin-α2-antiplasmin complex (PAP), and t-PA: PAI-1 complex (tPAI-C).According to the Clinical and

The relationship of plasma indicators of lipid metabolism and muscle damage to overnight temperature in winter-acclimatized small birds.

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Plasma glycerol and triglyceride levels and creatine kinase (CK) activity may increase during long-distance flights in migratory birds, but plasma profiles of these metabolites have not previously been reported for small birds during thermoregulation in cold climates. We measured early morning

Increased proportion of arachidonic acid in plasma lipids after 2 weeks on a diet of tropical seafood.

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Using capillary GLC we analyzed the plasma fatty acids in a group of full-blood Aborigines in north western Australia before and after 2 wk on a diet in which over 90% of the energy was derived from tropical fish and shellfish. The proportion of saturated fatty acids did not change and all monoenoic

Long-term treatment with pitavastatin is effective and well tolerated by patients with primary hypercholesterolemia or combined dyslipidemia.

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OBJECTIVE The primary objective was to assess the safety and tolerability of pitavastatin 4mg once daily during 52 weeks treatment. The secondary objectives were to assess the effect on lipid and lipoprotein fractions and ratios, and LDL-C target attainment. METHODS Patients with primary

Long-term safety and efficacy of fenofibric acid in combination with statin therapy for the treatment of patients with mixed dyslipidemia.

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BACKGROUND Co-administration of a fibrate and statin is an effective treatment option for patients with multiple lipid abnormalities, yet adequate long-term safety and efficacy data are lacking. OBJECTIVE To evaluate the long-term safety and efficacy of fenofibric acid combined with statins in

Environmental influences on hypothalamic-pituitary-thyroid function and behavior in Antarctica.

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We examined the physiological and psychological status of men and women who spent the summer (n=100) and/or winter (n=85) seasons in Antarctica at McMurdo (latitude 78.48 S, elevation 12 m) and South Pole (latitude 90 S, elevation 3880 m) stations to determine whether there were any significant

A 52-week placebo-controlled trial of evolocumab in hyperlipidemia.

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BACKGROUND Evolocumab, a monoclonal antibody that inhibits proprotein convertase subtilisin/kexin type 9 (PCSK9), significantly reduced low-density lipoprotein (LDL) cholesterol levels in phase 2 studies. We conducted a phase 3 trial to evaluate the safety and efficacy of 52 weeks of treatment with

Lipids seasonal variability in type 2 diabetes.

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OBJECTIVE The objective was to evaluate the seasonal lipid variations in type 2 diabetic (DM2) outpatients. METHODS 302 (183 women and 119 men) DM2 subjects with or without statins therapy were screened. Body weight, HbA1c, total cholesterol (TC), high density lipoprotein (HDL-C), triglycerides

Darunavir: a review of its use in the management of HIV infection in adults.

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Darunavir is an oral nonpeptidic HIV-1 protease inhibitor (PI) that is used, together with a low boosting dose of ritonavir, as part of an antiretroviral therapy (ART) regimen in treatment-experienced and -naive patients with HIV-1 infection. Compared with early-generation PIs, boosted darunavir has

Safety and tolerability of aripiprazole for irritability in pediatric patients with autistic disorder: a 52-week, open-label, multicenter study.

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OBJECTIVE Evaluate the long-term safety and tolerability of aripiprazole in the treatment of irritability in pediatric subjects (6-17 years) with autistic disorder. METHODS A 52-week, open-label, flexibly dosed (2-15 mg/d) study of the safety and tolerability of aripiprazole in outpatients with a

Comparative Effectiveness of Inclisiran 100, 300, and 500 mg in a Population with Hyperlipidemia: A Network Meta-Analysis of Randomized Controlled Trials.

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BACKGROUND To our knowledge, inclisiran was the first agent composed of small interfering RNAs (siRNAs) to be preliminarily used to reduce proatherogenic lipoprotein cholesterol levels. Inclisiran was evaluated in large clinical trials but did not receive government approval. The ability of

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