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Review article: use of antitumour necrosis factor therapy in inflammatory bowel disease during pregnancy and conception.

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BACKGROUND One of the most frequently asked questions during consultation with those affected by inflammatory bowel disease is what are its effects on pregnancy, and how the treatment will impact on conception and pregnancy outcomes. OBJECTIVE To review available data regarding the safety of

Birth Outcomes in Children Fathered by Men Treated with Anti-TNF-α Agents Before Conception.

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The safety of paternal use of anti-tumor necrosis factor-α (TNF-α) agents immediately prior to conception is practically unknown. On the basis of nationwide data from Danish health registries, we examined the association between paternal use of anti-TNF-α agents within 3 months before conception and

New pre-conception immune biomarkers for clinical practice: interleukin-18, interleukin-15 and TWEAK on the endometrial side, G-CSF on the follicular side.

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Identification of biomarkers of optimal uterine receptivity to the implanting embryo as well as biomarkers of oocyte competence would undoubtedly improve the efficiency of assisted reproductive technology (ART). Expression of IL-15 and IL-18 has been shown to be different in patients with failed

Distribution of Lipiodol and evidence for tumor necrosis in hepatocellular carcinoma.

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To study the distribution and thromboembolic effect of Ultrafluid Lipiodol, 15 surgically removed hepatocellular carcinomas with selective intraarterial Lipiodol injection 7 to 10 days before surgery and 15 noninjected controls were studied radiologically and histologically. Tissue blocks were

Can tumor necrosis factor inhibitors be safely used in pregnancy?

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OBJECTIVE We review available safety data for use of currently approved tumor necrosis factor (TNF) inhibitors during pregnancy and lactation and suggest guidelines for use of these agents among women of reproductive age. Method. Although regulatory agencies encourage the inclusion of pregnant women

Involvement of lipid peroxidation in necrosis of skin flaps and its suppression by ellagic acid.

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To evaluate the pathogenesis of lipid peroxidation in skin-flap necrosis and to select a novel herbal antioxidant to suppress lipid peroxidation and salvage the flaps, in vitro and in vivo experiments were instituted. In vitro studies revealed (1) the potentiality of the cutaneous microsomal system

Cytokine expression in the seminal plasma and its effects on fertilisation rates in an IVF cycle.

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Cytokines are released by various immunocompetent cell subsets in the male urogenital tract and are thought to affect sperm cell function and reproductive process. The aim of the study was to evaluate the levels and a possible role of seven seminal plasma cytokines with fertilisation rates in men

The effect of single nucleotide polymorphisms in the tumor necrosis factor-α gene on reproductive performance and immune function in dairy cattle.

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The present study aimed to assess the effect of polymorphisms in the tumor necrosis factor α (TNF-α) promoter (A/A, A/G and G/G) and exons (T/T, T/C and C/C) on immune function and reproductive performance in dairy cows. The occurrence of the first postpartum ovulation within 3 weeks in the cows

[Conception and course of eight pregnancies in five women on TNF blocker etanercept treatment].

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The introduction of tumor necrosis factor (TNF)-α inhibitors s in the late 1990s considerably broadened the treatment options for, and essentially contributed to the successful management of, rheumatoid arthritis (RA) and other immune-mediated inflammatory diseases. Nevertheless, their use during

Diagnostic imaging in uterine incisional necrosis/dehiscence complicating cesarean section.

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OBJECTIVE To review the diagnostic imaging studies in patients with surgically proven uterine incisional necrosis/dehiscence complicating cesarean section and to compare these studies with the findings at surgery. METHODS Over a 6-year period, the records of 7 patients with imaging studies prior to

[Pathological anatomy of femur head necrosis].

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Aseptic necrosis of the femoral head appears to have a number of etiological factors. The last steps of the pathogenetic course of events, however, is unclear. Histologically, small foci of marrow necrosis form repeatedly, particularly in the upper and medial zone of charge, and then fuse

The mode of death of epilepsy-induced "dark" neurons is neither necrosis nor apoptosis: an electron-microscopic study.

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Morphological aspects of the formation and fate of neurons that underwent dramatic ultrastructural compaction ("dark" neurons) induced by 4-aminopyridine epilepsy were compared in an excitotoxic and a neighboring normal-looking area of the rat brain cortex. In the excitotoxic area, the later the

Retained Products of Conception Fed by the Inferior Mesenteric Artery: A Case Report

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Retained products of conception (RPOC) refer to the persistence of placental or fetal tissue in the uterus following delivery or miscarriage. RPOC may cause massive postpartum or post-abortion hemorrhage. Arterial embolization (AE) is an effective choice of management for postpartum hemorrhage

Identification and characterisation of tumour necrosis factor receptor (TNFR) associated factor 3 from Nile tilapia, Oreochromis niloticus.

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In this study, we cloned the complementary (c)DNA sequences of tumour necrosis factor receptor (TNFR)-associated factor 3 (traf3) in Nile tilapia, Oreochromis niloticus. The expression patterns of the traf3 gene were investigated and preliminary functional analyses were performed. In healthy fish,

Tumour necrosis factor antagonists and inflammatory bowel diseases: a national practice survey.

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BACKGROUND Although the use of tumour necrosis factor (TNF) antagonists is increasingly codified, several unresolved issues remain. OBJECTIVE To conduct a French national survey on TNF antagonists use in inflammatory bowel disease (IBD). METHODS A postal questionnaire was sent to all French

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