Five patients, of any sex and age, with bilateral COVID-19 pneumonia, severe SIRA with PaO2 / FiO2 less than 150, lymphopenia less than 800 total lymphocytes, CT with bilateral pneumonia, SOFA less than 11 and that has not improved in relation to the following parameters: a) persistent PaO2 / FiO2 less than 150; b) persistent fever, c) increase in D-dimer of at least 50% of the baseline and / or ferritin greater than 1000, after 48 h of hospital stay receiving the standard management measures used at that time in the Care Center, will be included in the study. This treatment will be administered after discussing it with the relatives that it is a procedure considered as rescue and will be carried out with informed consent.

The results obtained in the treated group will be compared against the historical controls treated in INCMNSZ, evaluating the same variables.

Covid 19

Mesenchymal Stem cells from bank will be applied IV, at dose 1 million xKg in a single dose

Infusion IV of Mesenchymal Stem cells

Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

Mesenchymal Stem Cell for Acute Respiratory Distress Syndrome Due for COVID-19

Mesenchymal Stem Cells for the Treatment of Severe Acute Respiratory Distress Syndrome Due to COVID-19. Pilot Study

To describe the clinical changes secondary to IV administration of AMSCa, in patients with bilateral COVID-19 pneumonia complicated by severe SIRA, with the evaluation of the PaO2 / FiO2 ratio.

To describe the clinical changes secondary to IV administration of AMSCa, in patients with bilateral COVID-19 pneumonia complicated by severe SIRA, with the evaluation of the heart rate per minute.

To describe the clinical changes secondary to IV administration of AMSCa, in patients with bilateral COVID-19 pneumonia complicated by severe SIRA, with the evaluation of the respiratory rate per minute.

To describe the clinical changes secondary to IV administration of AMSCa, in patients with bilateral COVID-19 pneumonia complicated by severe SIRA, with the evaluation of the fever curve in degrees centigrade.

To assess the effect of the proposed treatment on the total Leukocytes

To assess the effect of the proposed treatment on absolute lymphocytes

To assess the effect of the proposed treatment on total platelets

To assess the effect of the proposed treatment on serum fibrinogen

To assess the effect of the proposed treatment on procalcitonin

To assess the effect of the proposed treatment on ferritin

To assess the effect of the proposed treatment on D-dimer

To assess the anti-inflammatory effect of the proposed treatment with assessment of the levels of C-reactive protein

To assess the anti-inflammatory effect of the proposed treatment with assessment of the levels of TNFa in plasma.

To assess the anti-inflammatory effect of the proposed treatment with assessment of the levels of IL10 in plasma.

To assess the anti-inflammatory effect of the proposed treatment with assessment of the levels of IL1 in plasma.

To assess the anti-inflammatory effect of the proposed treatment with assessment of the levels of IL6 in plasma.

To assess the anti-inflammatory effect of the proposed treatment with assessment of the levels of IL17 in plasma

To assess the anti-inflammatory effect of the proposed treatment with assessment of the levels of VEGF in plasma

Assess the radiological evolution of the proposed treatment through simple chest CT

Evaluate immune system improvement with mass cytometry to analyze patients' immune cells: regulatory T cells

Evaluate immune system improvement with mass cytometry to analyze patients' immune cells: dendritic cells

Evaluate immune system improvement with mass cytometry to analyze patients' immune cells: CD4 + T

Evaluate immune system improvement with mass cytometry to analyze patients' immune cells: CD8 + T

Evaluate immune system improvement with mass cytometry to analyze patients' immune cells: NK cells

Evaluate the safety of the proposed treatment (allergic reactions and / or infection)

To assess the negativization of the SARS-Cov2 PCR RNA detection test

Martín Iglesias

Plastic surgeon

Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran

Mesenchymal Stem Cell from umbilical cord allogenic from de bank laboratory, will be applied IV to 5 patients con pneumonia bilateral due to COVID 19, complicated with acute respiratory distress syndrome. The clinical, biochemical, inflammatory and immune changes will be described and compare against historical cases treated in the Instituto Nacional de Ciencias Medicas y Nutrición Salvador Zubirán

Lateral orbital injection of either Botox Cosmetic, 10 units or Dysport, 30 units as a single dose in a randomized (right or left sides) double blind fashion in 90 consecutive subjects

Intrinsic Aging of Skin

Solar Elastosis

Right lateral orbital injection of Botox Cosmetic or Dysport (10 units and 30 units, respectively) divided among 4 injection points (0.05 mL [7.5 units] per injection point) divided among 4 injection points (0.05mL [2.5units]) on Day 0 of the study

Right lateral orbital injection of Botox Cosmetic or Dysport

Left lateral orbital injection of Botox Cosmetic or Dysport (10 units and 30 units, respectively) divided among 4 injection points (0.05 mL [7.5 units] per injection point) divided among 4 injection points (0.05mL [2.5units]) on Day 0 of the study

Left lateral orbital injection of Botox Cosmetic or Dysport

The Maas Clinic

Onabotulinum Toxin Type A and Abobotulinum Toxin Type A Crow's Feet Rhytid Study

A Double Blinded Randomized Controlled Trial to Compare the Efficacy, Time to Onset, and Duration of Two Botulinum Type A Exotoxins (Onabotulinum Toxin A and Abobotulinum Toxin A) in the Treatment of "Crow's Feet."

Subject and investigator assessed grading as well as subject preference

contracture/ألبيومين

Mesenchymal Stem Cell for Acute Respiratory Distress Syndrome Due for COVID-19

Onabotulinum Toxin Type A and Abobotulinum Toxin Type A Crow's Feet Rhytid Study

A Randomized, Controlled Trial of Autologous Platelet Gel Treatment in Diabetic Foot Ulcers

قاعدة بيانات الأعشاب الطبية الأكثر اكتمالا التي يدعمها العلم