coumarin/نزف

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Risk factors for bleeding in patients taking coumarins.

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Coumarins (e.g., warfarin) are used for the treatment and prophylaxis of venous and arterial thromboembolism. Unfortunately, their use is limited by bleeding. In deciding whether to initiate coumarin therapy, the therapeutic benefits must be weighed against the potential risk of bleeding for each

Effect of oral antiplatelet agents on major bleeding in users of coumarins.

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Treatment with vitamin K antagonists (coumarins) is associated with an increased risk of bleeding. In order to elucidate the bleeding risk of users of antiplatelet drugs among users of coumarins, we assessed the odds ratio of major bleeding associated with use of antiplatelet drugs in users of the

Risk of major bleeding during concomitant use of antibiotic drugs and coumarin anticoagulants.

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BACKGROUND Coumarin anticoagulants are prone to drug-drug interactions. For example, antibiotic drugs may enhance the anticoagulant effect of coumarins. However, whether such interactions are associated with an increased risk of bleeding, and if so, how frequently this occurs remains

Parotid gland hemorrhage as a complication of coumarin compound ingestion.

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Bleeding in the salivary glands represents a very rare complication of oral anticoagulant therapy. Only one such case has been previously described in the submandibular glands. To the best of our knowledge, we document the first case of hemorrhage in the parotid gland following the ingestion of

Management of coumarin-associated coagulopathy in the non-bleeding patient: a systematic review.

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OBJECTIVE Excessive anticoagulation is a frequent complication of anticoagulant therapy. The risk of hemorrhage approximately doubles for each one point increase in the International Normalized Ratio (INR) above 3.0. Reducing a prolonged INR to within the desired therapeutic range requires that oral

Successful prevention of coumarin-induced hemorrhagic skin necrosis by timely administration of vitamin k1.

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Successful prevention of the progression of incipient hemorrhagic skin necrosis by timely administration of vitamin K1 in a woman treated with phenprocoumon is presented. From a critical review of the literature strong evidence emerges that coumarin necrosis does only occur in cases with severe

Total burden of intraplaque hemorrhage in coronary arteries relates to the use of coumarin-type anticoagulants but not platelet aggregation inhibitors.

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Intraplaque hemorrhage (IPH) is a crucial factor in progression and destabilization of an atherosclerotic plaque. Anti-thromboembolic drugs are widely used as prophylactic treatment against arterial and venous thrombotic diseases, but a major complication is bleeding. We investigated the association

Concomitant coumarin-NSAID therapy and risk for bleeding.

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OBJECTIVE To investigate the risk of bleeding complications during the combined use of coumarin derivatives and nonsteroidal antiinflammatory drugs (NSAIDs) compared with the use of coumarin derivatives alone. METHODS In this 1-year observational study, the local outpatient anticoagulation office

Leukocytoclastic vasculitis: another coumarin-induced hemorrhagic reaction.

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A 67-year-old male developed a hemorrhagic eruption 4 weeks after initiation of coumarin therapy. Examination revealed a well-demarcated, purple patch with a central hemorrhagic bulla on the anterior aspect of the leg, surrounded by small petechiae. Histological examination of the purple plaque

No Evidence for an Association Between Renal Function and Serious Bleeding Events in Patients Treated With Coumarins: A Population-Based Study.

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BACKGROUND Although anticoagulation therapy is closely monitored in the Netherlands, coumarin-induced serious bleeding events are still observed. Current literature suggests that renal impairment may contribute to this. OBJECTIVE To explore the association between renal function and bleeding events

Influence of the CYP4F2 polymorphism on the risk of hemorrhagic complications in coumarin-treated patients.

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OBJECTIVE To evaluate the impact of the CYP4F2 polymorphism on bleeding complications and over-anticoagulation due to coumarin. METHODS A comprehensive literature search was performed to look for eligible studies published prior to February 2015 in EMBASE and PubMed. References were strictly

Age and coumarin-type anticoagulation are associated with the occurrence of intraplaque hemorrhage, while statins are associated less with intraplaque hemorrhage: a large histopathological study in carotid and femoral plaques.

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BACKGROUND Intraplaque hemorrhage (IPH) is an important determinant of progression and destabilization of atherosclerotic plaque. We recently demonstrated that IPH is an independent predictor of future cardiovascular events after carotid endarterectomy. Thus far, it is unknown whether clinical

[Intracranial and intraspinal hemorrhages in treatment with coumarin derivatives. Catamnesis of 63 cases between 1978 and 1986].

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From 1978-1986, 63 patients (48-79 years) under coumarin derivatives had to be hospitalized neurosurgically because of intracranial or intraspinal bleedings. This corresponds to a twelvefold increased risk compared to the untreated people. The male/female ratio was 1.5. At the time of the bleeding

Diffuse alveolar hemorrhage in coumarin users: a fibrosing interstitial pneumonia trigger?

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BACKGROUND Fibrosing interstitial pneumonias (IPs) include idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP). It has been suggested that oxidative damage plays a role in the pathophysiology of idiopathic interstitial pneumonias. Diffuse alveolar hemorrhage (DAH) can

Hemorrhagic complications after intravitreal injections of ranibizumab in patients under coumarin-type anticoagulation.

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BACKGROUND It was the aim of this retrospective study to evaluate the risk of extra- or intraocular hemorrhages associated with intravitreal injections of ranibizumab in patients receiving anticoagulation therapy with coumarin derivatives. METHODS 149 injections were performed in 50 patients who had

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