dahlia coccinea/phosphatase

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Spirastrellolide A: revised structure, progress toward the relative configuration, and inhibition of protein phosphatase 2A.

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[structure: see text] The structure of spirastrellolide A, a novel macrolide isolated from the marine sponge Spirastrella coccinea, has been revised to accommodate new MS and chemical transformation data. Relative configurations of three major fragments of the molecule have been elucidated from

Synthesis of novel benzofuran isoxazolines as protein tyrosine phosphatase 1B inhibitors.

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PTPases are considered to be involved in the etiology of diabetes mellitus and neural diseases, such as Alzheimer's disease and Parkinson's disease. Therefore, PTPase inhibitors should be useful tools to study the role of PTPases in these diseases and other biological phenomena, and which can be

Chemical constituents from the roots of Kadsura coccinea with their protein tyrosine phosphatase 1B and acetylcholinesterase inhibitory activities.

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Kadsura coccinea (Lem.) A. C. Smith has been used as a tonic, decongestant, and digestive agent. The roots are also employed in traditional medicine to treat chronic enteritis, acute gastritis, duodenal ulcers, rheumatic pain in bone, and traumatic injuries. In the present study, we have described

Antidiabetic activity of cycloart-23-ene-3beta, 25-diol (B2) isolated from Pongamia pinnata (L. Pierre) in streptozotocin-nicotinamide induced diabetic mice.

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The aim of the present investigation was to evaluate the antidiabetic activity of cycloart-23-ene-3beta, 25-diol (called as B2) isolated from stem bark of Pongamia pinnata in streptozotocin-nicotinamide induced diabetic mice. Diabetes was induced in mice by injecting streptozotocin (200mg/kg, i.p.)

Gastroprotective Properties of Karanjin from Karanja (Pongamia pinnata) Seeds; Role as Antioxidant and H, K-ATPase Inhibitor.

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Plant extracts are the most attractive sources of newer drugs and have been shown to produce promising results for the treatment of gastric ulcers. Karanjin, a furano-flavonoid has been evaluated for anti-ulcerogenic property by employing adult male albino rats. Karanjin (>95% pure) was administered

Stomatal response to blue light in crassulacean acid metabolism plants Kalanchoe pinnata and Kalanchoe daigremontiana.

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Blue light (BL) is a fundamental cue for stomatal opening in both C3 and C4 plants. However, it is unknown whether crassulacean acid metabolism (CAM) plants open their stomata in response to BL. We investigated stomatal BL responses in the obligate CAM plants Kalanchoe pinnata and Kalanchoe

Toxicological analysis and effectiveness of oral Kalanchoe pinnata on a human case of cutaneous leishmaniasis.

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Leishmaniasis is an extremely difficult disease to treat. Previously, it was shown that oral Kalanchoe pinnata (Kp) leaf extract is strongly effective against murine leishmaniasis. Here, it is shown that the serum levels of alanine-aminotransferase (ALT), aspartate-aminotransferase (AST), urea and

Acute and sub-acute toxicity studies of the methanol extract of the leaves of Paullinia pinnata (Linn.) in Wistar albino mice and rats.

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BACKGROUND The aim of this study was to investigate the toxicological effects of the leaves of Paullinia pinnata Linn.(PP) in rodents using Wistar albino mice and rats as experimental models. METHODS Acute toxicity study of the methanol extract of PP was carried out in Wistar strain albino mice

Sedoheptulose accumulation under CO₂ enrichment in leaves of Kalanchoë pinnata: a novel mechanism to enhance C and P homeostasis?

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In contrast to the well-documented roles of its mono- and bisphosphate esters, the occurrence of free sedoheptulose in plant tissues remains a matter of conjecture. The present work sought to determine the origin of sedoheptulose formation in planta, as well as its physiological importance. Elevated

Modulatory effects of ixora coccinea flower on cyclophosphamide-induced toxicity in mice.

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The active fraction of Ixora coccinea flowers showed chemoprotective effects on cyclophosphamide - induced toxicity by increasing the life span of treated mice, preventing body weight loss and maintaining near normal leucocyte and haemoglobin levels compared with cyclophosphamide treated controls.

Modulatory effects of lxora coccinea flower on Cyclophosphamidetoxicity in tumour bearing mice.

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The active fraction (AF) from lxora coccinea flowers prevented the decrease in haemoglobin levels and leucocyte counts of Dalton's lymphoma tumour bearing mice, treated with cyclophosphamide (CYP). It also significantly increased the life span of tumour bearing mice, treated with cyclophosphamide.

Hepatoprotective effect of three herbal extracts on aflatoxin B1-intoxicated rat liver.

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BACKGROUND Roots of Ixora coccinea (Rubiaceae), and Rhinacanthus nasuta (Acanthaceae) and whole plants of Spilanthes ciliata (Asteraceae) are extensively used by tribal communities in South India to treat liver diseases. However, the veracity of these tribal claims has not been investigated

Protection of hepatotoxicity using Spondias pinnata by prevention of ethanol-induced oxidative stress, DNA-damage and altered biochemical markers in Wistar rats.

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BACKGROUND Traditional systems of medicine use herbal drugs for hepatoprotection. Thus, the study was designed to evaluate the hepatoprotective and antioxidant effects of Spondias pinnata bark extracts against ethanol-induced liver injury in Wistar rats. METHODS Group I animals were treated with 1

Identification of pongamol and karanjin as lead compounds with antihyperglycemic activity from Pongamia pinnata fruits.

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OBJECTIVE To identify pongamol and karanjin as lead compounds with antihyperglycemic activity from Pongamia pinnata fruits. METHODS Streptozotocin-induced diabetic rats and hyperglycemic, hyperlipidemic and hyperinsulinemic db/db mice were used to investigate the antihyperglycemic activity of

Phosphorus uptake in four tree species under nitrogen addition in subtropical China.

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Atmospheric N deposition is a serious problem in subtropical China where N is present in large amounts but P is deficient. Several studies hypothesized that N2 fixers can overcome phosphorus limitation by trading fixed N2 for soil phosphorus. In order to know whether N2 fixers could invest fixed N2

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