BACKGROUND
I. Field of the Invention
The present invention relates generally to the fields of virology and therapeutics. More particularly, it concerns small molecule inhibitors of Dengue virus protease for treating flavivirus infections.
II. Description of Related Art
Flavivirus is a genus of the
REFERENCE TO SEQUENCE LISTING
None.
BACKGROUND
I. Field of the Invention
The present invention relates generally to the fields of virology and therapeutics. More particularly, it concerns small molecule inhibitors of Dengue and West Nile virus protease for treating flavivirus infections.
II.
TECHNICAL FIELD
This invention relates to molecular and cellular biology, biochemistry, molecular genetics, and drug design and discovery. In one aspect, the invention is directed to compositions, e.g., multiplexed platforms or systems, to screen for small molecule drugs that inhibit enzymes such as
BACKGROUND
The mosquito-borne dengue virus serotypes 1-4 (DENV1-4) are included in the National Institute of Allergy and Infectious Disease (NIAID) list of Category A, B, or C emerging human pathogens along with yellow fever virus (YFV), West Nile virus (WNV), and Japanese encephalitis virus (JEV).
TECHNICAL FIELD
The present invention relates to the field of therapeutic peptides. More specifically, this invention appertains to short-chain peptides capable of obstructing the bindable regions of flavivirus envelope glycoproteins, such as the E protein of dengue and Zika viruses, a class II
BACKGROUND
Flaviviruses such as West Nile virus (WNV), Japanese Encephalitis virus, and Dengue virus (e.g., the four known serotypes of Dengue virus (DEN-1-4)) are significant human pathogens that cause millions of infections each year and result in considerable morbidity and mortality. DEN viruses
BACKGROUND
Flaviviruses such as West Nile virus (WNV), Japanese Encephalitis virus, and Dengue virus (e.g., the four known serotypes of Dengue virus (DEN-1-4)) are significant human pathogens that cause millions of infections each year and result in considerable morbidity and mortality. DEN viruses
اكتب أحد الأعراض أو المرض واقرأ عن الأعشاب التي قد تساعد ، واكتب عشبًا واطلع على الأمراض والأعراض التي تستخدم ضدها. * تستند جميع المعلومات إلى البحوث العلمية المنشورة