Compounds of the formula (I) ##STR1##wherein A, R, R.sup.1, R.sup.2, X.sup.1, X.sup.2, X.sup.3, and Y are as defined herein, and the tautomers and the pharmaceutically acceptable salts thereof, including pharmaceutical compositions containing these compounds, and their use in the selective antagonization of calcitonin gene-related peptide (CGRP) and in the treatment or prophylaxis of migraine or cluster headaches, non-insulin-dependent diabetes mellitus, inflammation, allergic rhinitis, asthma, morphine tolerance, menopausal hot flashes, and diseases characterized by excessive vasodilatation and consequent reduction in blood-flow.

diabetes mellitus type 1/صداع

Antagonists of calcitonin gene-related peptide

قاعدة بيانات الأعشاب الطبية الأكثر اكتمالا التي يدعمها العلم