Clinico-epidemiological Characteristics of Corrosive Patients Presenting at Assiut Governorate

assessment of development of complications

development of complications or not

Evaluation of Esophageal Injuries in Corrosives in Assiut Governorate - Experimental Comparison Between Different Treatments

development of esophageal stricture or not

MKMAbdelrahim

assistant lecturer

Assiut University

Liquid nitrogen spray cryotherapy with the truFreeze device

Liquid nitrogen spray cryotherapy with the truFreeze device
Liquid nitrogen spray cryotherapy with the truFreeze device: Low-pressure liquid nitrogen is sprayed through an upper endoscope on the diseased esophageal tissue to freeze and destroy it. The upper endoscope enables direct visualization of mucosal freeze during spray of the liquid nitrogen onto the mucosa and avoids the need for direct contact with the tissues. The target area is frozen and thawed for several consecutive cycles. The treated tissue becomes necrotic and sloughs, with new, healthy tissue regenerating in its place.

Cryotherapy

Sex: Female, Male

Race and Ethnicity Not Collected

The primary endpoint is to determine the response rate to spray cryotherapy.
It is hypothesized that one of the two following outcomes will occur:
Complete response to therapy: complete tumor eradication confirmed through histologic examination of biopsy specimens from the targeted esophageal tissue site;
Stable disease: tumor remission is not attained, but disease progression is halted.

Treated with liquid nitrogen spray cryotherapy

Treatment

Response Rate to Therapy

Disease-free Survival at 12 Months After Treatment

Cancer Recurrence Rate at 12 Months After Treatment

Estimate Overall Survival

Estimate Progression-free Survival in Those Who do Not Achieve Complete Pathologic Response

Number of Treatment Sessions Needed for Complete Response in Subjects in Whom the Primary Endpoint is Attained;

Number of participants with adverse events; Number of adverse events within the study

Safety of Spray Cryotherapy in This Setting;

Overall Study

Dr. Bruce Greenwald

Esophageal Cancer

Low-pressure liquid nitrogen is sprayed through an upper endoscope on the diseased esophageal tissue to freeze and destroy it. The upper endoscope enables direct visualization of mucosal freeze during spray of the liquid nitrogen onto the mucosa and avoids the need for direct contact with the tissues. The target area is frozen and thawed for several consecutive cycles. The treated tissue becomes necrotic and sloughs, with new, healthy tissue regenerating in its place.

University of Maryland Medical Center

Spray Cryotherapy for Esophageal Cancer (ICE-CANCER)

A Phase II, Multi-Center Study of Interventional Spray Cryotherapy for Early-Stage Esophageal Cancer (ICE-CANCER)

Bruce Greenwald

Professor of Medicine

University of Maryland, Baltimore

Subjects will receive two 5mg tablets of Montelukast/day.

Subjects will receive one 5mg tablet of montelukast and 1 placebo tablet per day.

Subjects will receive two placebo tablets per day.

Eosinophilic Esophagitis

Those in Montelukast 10mg/day group will receive two 5mg tablets of Montelukast.

Montelukast

Those in the placebo group will receive 2 placebo tablets per day. Those in the Montelukast 5mg/day will receive 1 placebo tablet per day.

placebo

Subject will receive one 5mg tablet of Montelukast and one placebo tablet per day.

esophageal stenosis/تقيؤ

Evaluation of Esophageal Injuries in Corrosives in Assiut Governorate - Experimental Comparison Between Different Treatments

Spray Cryotherapy for Esophageal Cancer (ICE-CANCER)

A Trial of Montelukast for Maintenance Therapy of Eosinophilic Esophagitis in Children

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