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Treatment of pediatric epilepsy: European expert opinion, 2007.

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BACKGROUND Childhood epilepsies are a heterogeneous group of conditions that differ in diagnostic criteria and management and have dramatically different outcomes. Despite increasing data on treatment of epilepsy, research findings on childhood epilepsy are more limited and many clinical questions

The European patient with Dravet syndrome: results from a parent-reported survey on antiepileptic drug use in the European population with Dravet syndrome.

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Dravet syndrome is a rare form of epilepsy largely refractory to current antiepileptic medications. The only precedents of randomized placebo-controlled trials in Dravet syndrome are the two small trials that led to the approval of stiripentol. With the arrival of new clinical trials for Dravet

Rufinamide for refractory focal seizures: an open-label, multicenter European study.

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OBJECTIVE The present study aimed to assess the efficacy and tolerability of rufinamide as adjunctive drug for the treatment of a large series of children, adolescents and adults with refractory cryptogenic or symptomatic focal epilepsy. METHODS Patients were recruited in a prospective, add-on,

Could Adult European Pharmacoresistant Epilepsy Patients Be Treated With Higher Doses of Zonisamide?

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OBJECTIVE To examine the clinical effect (efficacy and tolerability) of high doses of zonisamide (ZNS) (>500 mg/d) in adult patients with pharmacoresistant epilepsy. METHODS Between 2006 and 2013, all epileptic outpatients treated with high doses of ZNS were selected. Safety and efficacy were

Effects of vagal stimulation on swimbladder blood flow in the european eel Anguilla anguilla.

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The influence of the vagus nerve on swimbladder blood flow in the European eel (Anguilla anguilla) was characterized by recording the changes in blood flow rate and blood pressure following stimulation of the vagus nerve. After electrical stimulation, blood flow in the swimbladder artery increased

Absence of linkage to 8q24 in a European family with familial adult myoclonic epilepsy (FAME).

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BACKGROUND Familial adult myoclonic epilepsy (FAME) is defined by autosomal dominant inheritance, adult onset of myoclonus of the extremities, infrequent epileptic seizures, nonprogressive course, abnormality of polyspikes and waves on examination by EEG and photosensitivity, giant somatosensory

Clinical efficacy of topiramate as add-on therapy in refractory partial epilepsy: the European experience.

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In three randomized, double-blind, placebo-controlled add-on European trials, target daily topiramate (TPM) dosages of 400, 600, and 800 mg/day (200, 300, and 400 mg bid) were evaluated in adults with refractory partial seizures with or without becoming secondarily generalized. Median reductions

Tonotopic organization and functional characterization of the auditory thalamus in a songbird, the European starling.

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1. The diencephalic auditory nucleus of the European starling, the nucleus ovoidalis, shows rostrocaudal and dorsoventral diameters of 500-800 microns and a mediolateral diameter of 800-1000 microns. This small and sharply delimited nucleus is composed of densely packed neurons. 2. Its tonotopic

Relationships between diurnal changes in blood pressure and catecholamines among Filipino-American and European-American women.

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OBJECTIVE Studies show that diurnal blood pressure (BP) sensitivity to epinephrine (EPI) in African-American women is significantly greater than that of European-American (EA) women. Few if any studies have examined diurnal catecholamine-BP relationships in women of other ethnic groups. The purpose

Visual system of the European hummingbird hawkmoth Macroglossum stellatarum (Sphingidae, Lepidoptera): motion-sensitive interneurons of the lobula plate.

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The European hummingbird hawkmoth Macroglossum stellatarum is a member of the sphingid family, denoted by their ability to hover in place in front of flowers. The fast and acrobatic flight behavior is thought to be under the control of the optomotor system both during normal, forward flight and

Effects of suspended matter quality and virus abundance on microbial parameters: experimental evidence from a large European river.

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In riverine water, both suspended particulate material and viruses are prominent ecological factors. The existence of various particle types and differences in viral abundance impose variability in microenvironments. Particulates and their microbial surrounding may interact in several ways, this

First European case of convulsions related to analytically confirmed use of the synthetic cannabinoid receptor agonist AM-2201.

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OBJECTIVE There is increasing reported use of synthetic cannabinoid receptor agonists (SCRA) across Europe. To date, there is limited information on the acute toxicity (harm) related to the use of these products. We describe here a case in which an individual developed convulsions related to the use

Nutritional composition of the food supply: a comparison of soft drinks and breakfast cereals between three European countries based on labels.

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Monitoring of processed products at the brand level was implemented in Austria, France and Romania on the basis of the Oqali methodology during the Joint Action on Nutrition and Physical Activity (JANPA) to compare the nutritional quality of the food offering. The objective of this

Contributions of testosterone and territory ownership to sexually-motivated behaviors and mRNA expression in the medial preoptic area of male European starlings.

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Animals integrate social information with their internal endocrine state to control the timing of behavior, but how these signals are integrated in the brain is not understood. The medial preoptic area (mPOA) may play an integrative role in the control of courtship behavior, as it receives

QT interval variability in body surface ECG: measurement, physiological basis, and clinical value: position statement and consensus guidance endorsed by the European Heart Rhythm Association jointly with the ESC Working Group on Cardiac Cellular Electrophysiology.

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This consensus guideline discusses the electrocardiographic phenomenon of beat-to-beat QT interval variability (QTV) on surface electrocardiograms. The text covers measurement principles, physiological basis, and clinical value of QTV. Technical considerations include QT interval measurement and the

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