Metformin 850mg PO three times a day, during the pre-induction with steroids, induction remission, consolidation and maintenance

Acute Lymphoblastic Leukemia

Metformin 850 mg PO three times a day plus prednisone in one 7-days cycle as pre-treatment and during the 28 days induction remission treatment, consolidation therapy and maintenance

Metformin

Metformin Reduce the Relapse Rate on Patients With B-cell Precursor (Ph+ Negative) Acute Lymphoblastic Leukemia

Effect of the Addition of Metformin Hydrochloride on the Prognosis of Patients With B-cell Precursor (Ph+ Negative) Acute Lymphoblastic Leukemia With High Expression of ABCB1 Gene

Effect on the refractoriness frequency in high risk failure patients (High levels of ABCB1)

Effect of Metformin on Relapse Free Survival (RFS) on patients with high risk failure (high levels of ABCB1 gene )

Christian Ramos Penafiel

Principal Investigator

Hospital General de Mexico

Patients receive digital rectal palpation and then void a spontaneous urine sample for PMU analysis. Patients then undergo a prostate biopsy.

Patients receive DRE with prostatic massage for 30-60 seconds and are then milked at the urethra to provide a collection of EPS. Patients then undergo a prostate biopsy.

Conditions Influencing Health Status

Healthy

Prostate Cancer

laboratory biomarker analysis

transrectal prostate biopsy

Chinn & Chinn Urology Associates, Inc.

City of Hope Medical Center

Citrus Valley Urologic Medical Group

Dr. Felix Chi-Ming Yip

City of Hope- South Pasadena Cancer Center

Comparing the Reliability of Expressed Prostatic Secretion (EPS) and Post Massage Urine (PMU) for the Prediction of Prostate Cancer Biopsy Outcome

Compare assay results in 300 EPS specimens with those from 300 PMU specimens. The gold standard for assay validity is the biopsy result.

Perform TMPRSS2:ERG type III and TMPRSS2:ERG type IV assays on each specimen. The gold standard for assay validity is the biopsy result.

The gold standard for assay validity is the biopsy result.

National Cancer Institute (NCI)

Patients treated for prostatic pathology (benign or malign)in the hospital department.

Benign Prostatic Hypertrophy

Urine specimens collected by vesical catheterism just before surgery. The dosage of PCA-3 and the analyse of several prostatic markers (genes coding for androgen receptor and steroid alpha-reductase type 1 and 2) will be realized on the samples of urines.

glyceraldehyde/سرطان

Metformin Reduce the Relapse Rate on Patients With B-cell Precursor (Ph+ Negative) Acute Lymphoblastic Leukemia

Comparing the Reliability of Expressed Prostatic Secretion (EPS) and Post Massage Urine (PMU) for the Prediction of Prostate Cancer Biopsy Outcome

Prostate Cancer Antigen 3 (PCA-3) Gene Project

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