The present invention is directed to compositions and methods for measuring enzymatic activity, particularly glycosidase activity. Methods of the present invention include assays for quantitatively determining the amount of glycosidase activity in a sample. The present invention also provides methods for the diagnosis of metastatic and inflammatory processes in vitro and in vivo. The present invention further provides compositions and methods for high throughput assays for identifying compounds that effect glycosidase activity.

Reddy US Therapeutics, Inc.

Methods and compositions for glycosidase assays

Qualitative and quantitative methods of testing an agent for its potential at inhibiting glycosidase catalytic activity, the methods including the steps of interacting a glycosidase enzyme with a glycosidase substrate in a presence of the agent and qualitatively or quantitatively evaluating an effect of the agent on the catalytic activity of the glycosidase enzyme toward the glycosidase substrate. Preferably the glycosidase enzyme is a heparanase enzyme and the glycosidase substrate is, respectively, a heparanase substrate.

Insight Strategy &amp; Marketing Ltd.

glycosidase/التهاب

Methods and compositions for glycosidase assays

Method of screening for potential anti-metastatic and anti-inflammatory agents using mammalian heparanase as a probe

قاعدة بيانات الأعشاب الطبية الأكثر اكتمالا التي يدعمها العلم