glycosuria/سمنة

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Exploring glycosuria as a mechanism for weight and fat mass reduction. A pilot study with remogliflozin etabonate and sergliflozin etabonate in healthy obese subjects.

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Inhibitors of sodium-dependent glucose co-transporter 2 (SGLT2) increase glucose excretion in the urine and improve blood glucose in Type 2 diabetes mellitus. Glycosuria provides an energy and osmotic drain that could alter body composition. We therefore conducted a pilot study comparing the effects

Associations of gestational diabetes, existing diabetes, and glycosuria with offspring obesity and cardiometabolic outcomes.

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OBJECTIVE To assess associations of gestational diabetes, existing diabetes, and glycosuria with adiposity and cardiometabolic risk factors in offspring at adolescence. METHODS Multivariable regression analyses were conducted in a prospective pregnancy cohort (n = 2,563-4,198 for different

The obstetric importance of obesity and benign glycosuria in prediagnosis diabetes.

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Is there a role for glycosuria testing in sub-Saharan Africa?

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BACKGROUND With increasing urbanization and westernization, rates of diabetes in sub-Saharan Africa (sSA) are likely to rise. Early detection and intervention plays an important role in delaying development of complications. In sSA in particular there is need for an affordable, reliable, safe,

A new spontaneous animal model of NIDDM without obesity in the musk shrew.

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The EDS (early-onset diabetes in suncus) colony has been developed as a new closed breeding colony of the musk shrew (Suncus murinus, Insectivora) exhibiting a high incidence of spontaneous diabetes mellitus. We investigated the characteristic features of diabetic shrews in this colony. All diabetic

Treatment of type 1 diabetes mellitus in non-obese diabetic mice by transplantation of allogeneic bone marrow and pancreatic tissue.

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Non-obese diabetic (NOD) mice provide a model for type 1 diabetes mellitus. We previously showed that allogeneic bone marrow transplantation (ABMT) can prevent and treat insulitis and overt diabetes in NOD mice. However, ABMT alone could not be used to treat overt diabetes in NOD mice whose islets

Changes in the growth hormone-IGF-I axis in non-obese diabetic mice.

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We investigated the changes in GH-IGF-I axis in non-obese diabetic (NOD)-mice, a model of insulin-dependent diabetes mellitus. Diabetic female NOD mice and their age- and sex-matched controls were sacrificed at 4, 14, 21 and 30 days (30d DM) after the onset of glycosuria. Serum GH levels increased

A prospective study of health check examinees for the development of non-insulin-dependent diabetes mellitus: relationship of the incidence of diabetes with the initial insulinogenic index and degree of obesity.

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A total of 1788 non-diabetic subjects, screened by a general health check, had either glycosuria or marginal elevation of fasting blood glucose and/or HbA1c. They were followed by repeated 100 g oral glucose tolerance tests for up to 8 years. Their initial mean age was 52 years and the mean BMI was

Reduced renal sympathetic nerve activity contributes to elevated glycosuria and improved glucose tolerance in hypothalamus-specific Pomc knockout mice.

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Hypothalamic arcuate nucleus-specific pro-opiomelanocortin deficient (ArcPomc-/-) mice exhibit improved glucose tolerance despite massive obesity and insulin resistance. We demonstrated previously that their improved glucose tolerance is due to elevated glycosuria. However, the underlying mechanisms

Type 2 diabetes and obesity in children and adolescents: experience from studies in Taiwanese population.

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Global prevalence of type 2 diabetes mellitus in children is rising recently, likely due to an increasing rate of childhood obesity. In Taiwan, an annual program of mass screen for diabetes with two-staged design, i.e. diagnosis by fasting plasma glucose when glycosuria was positive in two

Experimental hypothalamic or genetic obesity in the non-insulin-dependent diabetic rat.

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Non-insulin-dependent diabetes was obtained in adult rats by neonatal administration of streptozotocin (100 mg/kg). Obesity was obtained in the same animals either by a ventromedial hypothalamic lesion in adult non-insulin-dependent diabetic Wistar rats, or by using genetically obese Zucker rats. In

[Glycosylated hemoglobin in pregnant women with glycosuria].

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Systematic assays of glycosylated haemoglobin were performed to verify that pregnant women with glycosuria and normal fasting blood glucose and glucose tolerance tests had no disturbances in glycoregulation . Glycosylated haemoglobin levels were measured in 25 glycosuric women on the second (n = 11)

Relevance of postprandial glycosuria in survey for diabetes mellitus.

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Since the oral glucose tolerance test is not applicable in large surveys for diabetes mellitus, economic tests or clinical criteria are required to select subjects needing a complete glycometabolic assessment. This study evaluated, in a selected high risk population (110 subjects; 71 males; median

Obesity and its obstetric implications.

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Obesity has long been regarded as an obstetric hazard. This study identified 300 primipara patients aged 20-29 years who were classified according to the estimated pre-pregnancy Body Mass Index (BMI). The study population was sub-divided into the lean (BMI < 25 kg/m2, n = 189), the overweight group

Simultaneous characterization of metabolic, cardiac, vascular and renal phenotypes of lean and obese SHHF rats.

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Individuals with metabolic syndrome (MetS) are prone to develop heart failure (HF). However, the deleterious effects of MetS on the continuum of events leading to cardiac remodeling and subsequently to HF are not fully understood. This study characterized simultaneously MetS and cardiac, vascular

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