Oral propranolol 1mg/kg/day as crushed tablets, in two divided doses, increased to 2mg/kg/day in two divided doses after 24 hours if tolerated well. Treatment will be stopped at complete clinical clearance of lesion (defined arbitrarily as >90% reduction in the size of Infantile Hemangioma as assessed by Physician Global Assessment) or after 9 months of treatment (primary end point) whichever is earlier.

Oral atenolol 0.5mg/kg as a single dose, increased to 1mg/kg as a single dose after 24 hours if tolerated well. Treatment will be stopped at complete clinical clearance of lesion (defined arbitrarily as >90% reduction in the size of Infantile Hemangioma as assessed by Physician Global Assessment) or after 9 months of treatment (primary end point) whichever is earlier.

Infantile Hemangioma

oral propranolol 1-2mg/kg/day as crushed tablets in two divided doses

oral propranolol

oral atenolol 0.5-1mg/kg/day as crushed tablets in a single dose

oral atenolol

PGIMER

Comparative Study to Evaluate the Effectiveness of Atenolol and Propranolol in the Treatment of Infantile Hemangiomas

Physician Global Assessment
Responses to therapy (change of thickness, color, and area) will be recorded on each follow up.The therapeutic responses will be evaluated on a score of 1-5 as follows by an independent dermatologist who will not know the therapies:
Score 5: >90% improvement or complete clinical involution Score 4: excellent improvement(75-90% decrease) Score 3: good improvement(50-74% decrease) Score 2: minimal improvement( 25-49% decrease) Score 1: poor improvement(1-24% decrease) Score 0: failure (no difference or regrowth)

Hemangioma Activity score
Patient name:
Age:
Location of infantile hemangioma:
("Bright red edge" should only be scored when the HOI is not totally "bright red" Skin colored after activity". Do not score in deep HOI (deep swelling) unless the HOI has changed into it after activity)
Date
Deep swelling:
tense HOI(6) 'neutral' HOI at t=0 or less than 50% reduction at follow up(4) >=50% reduction at follow up (2) No more swelling at follow up (0)
Bright red/ shining red HOI(5) OR bright red edge(4) Matt red/reddish purple HOI/ matt red edge(3) Blue HOI or Blue shining through in deep HOI(2) Grey HOI(1) Skin colored after activity(0)
Total score:
Number of items scored Preliminary HAS= total score/number of items scored
Ulcer=<1cm2 (+0.5) Ulcer 1-25cm2(+1) Ulcer >=25cm2(+2) HAS= preliminary HAS + ulcer score

Raihan Ashraf

Junior Resident, Department of Dermatology

Postgraduate Institute of Medical Education and Research

Propranolol was administered orally as a dose of 1.5 mg/kg.d divided q8h. investigators used powdered drug, dissolved in 5% dextrose. The treatment was continued until complete development of retinal vascularization, although administration was not permitted for more than 90 days.

Retinopathy of Prematurity

Propranolol was administered orally as a dose of 1.5 mg/kg.d divided q8h.investigators used powdered drug, dissolved in 5% dextrose. The treatment was continued until complete development of retinal vascularization, although administration was not permitted for more than 90 days.

hemangioma/نقص الأكسجة

Comparative Study to Evaluate the Effectiveness of Atenolol and Propranolol in the Treatment of Infantile Hemangiomas

Oral Propranolol Improve Retinopathy of Prematurity Outcomes in Very Preterm Infants

قاعدة بيانات الأعشاب الطبية الأكثر اكتمالا التي يدعمها العلم