Vegan subjects interveinted with oral capsules of BCAA, 15 (women) or 20 (men) grams daily for 3 months

Omnivorous subjects iterveined with oral capsules of BCAA, 15 (women) or 20 (men) grams daily for 3 months

Type 2 Diabetes Mellitus With Features of Insulin Resistance

15 (women) or 20 (men) grams of BCAA daily for 3 months

branched chain amino acids

Centre fo Research on Diabetes, Metabolism and Nutrition, 3rd Faculty of Medicine, Charles University

Effects of Chronic Dietary Exposure to Branched Chain Amino Acids

Effects of Chronic Dietary Exposure to Branched Chain Amino Acids on Insulin Sensitivity Measures in Healthy Vegans and Omnivores

glucose clamp technique; summarized in methods elsewhere

activity of electron transport chain complexes and citrate synthase, spectroscopy; summarized in methods elsewhere

Insulin function (IRS1, GLUT4), BCAA metabolism (BCKDHA, BCKDHB), fatty acid oxidation (ACOX, CPT1b) and lipogenesis (perilipin: PLIN2, PLIN5). All assessed by RT PCR, all in delta delta Ct method; summarized in methods elsewhere

glucose uptake (IRS1, GLUT4), BCAA metabolism (BCKDHA, BCKDHB) and lipogenesis (PPAR-γ, fatty acid synthase, stearoyl-coenzyme A desaturase 1 and 5, diglycerol acyl transferase 2, perilipin: PLIN1, PLIN2). All assessed by RT PCR, all in delta delta Ct method; summarized in methods elsewhere

MUDr. Radka Straková

Charles University, Czech Republic

One arm study in Overweight Type 2 Diabetes Mellitus

Overweight Type 2 Diabetes Mellitus

Sex: Female, Male

Region of Enrollment

Change: Weight after 12 months of therapy or more - weight at baseline

Change in Weight From Baseline at 12 Months or More

Change: Body Mass Index (BMI) after 12 months of therapy or more - BMI at baseline

Change in Body Mass Index (BMI) From Baseline at 12 Months or More

Change: Waist circumference after 12 months or more of therapy - Waist circumference at baseline

Change in Waist Circumference From Baseline at 12 Months or More

Change: Waist circumference/Hip circumference ratio after 12 months or more of therapy - Waist circumference/Hip circumference ratio at baseline

Change in Waist Circumference (Cms)/Hip Circumference (Cms)From Baseline at 12 Months or More

Change: Waist/Height ratio after 12 months or more of therapy - Waist/Height ratio at baseline

Change in Waist (Cms) /Height (Meters) Ratio From Baseline at 12 Months or More

Change: Fasting blood glucose after 12 months or more of therapy - Fasting blood glucose at baseline

Change in Fasting Blood Glucose From Baseline at 12 Months or More

Change: Glycosylated Haemoglobin after 12 months or more of therapy - Glycosylated Haemoglobin at baseline.

Change in Glycosylated Haemoglobin (A1C) From Baseline at 12 Months or More

Metformin in Maximum Tolerated Dose

Metformin for 12 Months or More

Dr. Amulya R Sircar

Obesity

Type 2 Diabetes Mellitus

0.5g twice a day to 2g twice a day for at least 12 months or more

Extended Release Metformin

Sircar Diabetes Clinic

Metformin in Overweight Type 2 Diabetes Mellitus

Metformin Monotherapy Significantly Improves Anthropometric and Glycemic Values in Overweight Type 2 Diabetes Mellitus: One Year or More Prospective Study.

hexokinase/إعياء

Effects of Chronic Dietary Exposure to Branched Chain Amino Acids

Metformin in Overweight Type 2 Diabetes Mellitus

Measurement of Outcome of Surgical Treatment in Patients With Acromegaly

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